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Título: | Leishmania major self-limited infection increases blood cholesterol and promotes atherosclerosis development. |
Autor(es): | Fernandes, Luciana Rodrigues Ribeiro, Ana Cecília de Castro Segatto, Marcela Santos, Luís Felipe F. F. Amaral, Joana Ferreira do Portugal, Luciane Rodrigues Leite, Jacqueline Isaura Alvarez |
Data do documento: | 2013 |
Referência: | FERNANDES, L. R. et al. Leishmania major self-limited infection increases blood cholesterol and promotes atherosclerosis development. Cholesterol, v. 2013, p. 1-9, 2013. Disponível em: <http://www.hindawi.com/journals/cholesterol/2013/754580/>. Acesso em: 08 nov. 2014. |
Resumo: | Leishmania major infection of resistant mice causes a self-limited lesion characterized by macrophage activation and a Th1 proinflammatory response. Atherosclerosis is an inflammatory disease involving hypercholesterolemia and macrophage activation. In this study, we evaluated the influence of L. major infection on the development of atherosclerosis using atherosclerosissusceptible apolipoprotein E-deficient (apoE KO) mice. After 6 weeks of infection, apoE KO mice exhibited reduced footpad swelling and parasitemia similar to C57BL/6 controls, confirming that both strains are resistant to infection with L.major. L.majorinfected mice had increased plasma cholesterol levels and reduced triacylglycerols. With regard to atherosclerosis, noninfected mice developed only fatty streak lesions, while the infected mice presented with advanced lesions containing a necrotic core and an abundant inflammatory infiltrate. CD36 expression was increased in the aortic valve of the infected mice, indicating increased macrophage activation. In conclusion, L. major infection, although localized and self-limited in resistant apoE KO mice, has a detrimental effect on the blood lipid profile, increases the inflammatory cell migration to atherosclerotic lesions, and promotes atherogenesis.These effects are consequences of the stimulation of the immune system by L. major, which promotes the inflammatory components of atherosclerosis, which are primarily the parasite-activated macrophages. |
URI: | http://www.repositorio.ufop.br/handle/123456789/4689 |
DOI: | http://dx.doi.org/10.1155/2013/754580 |
ISSN: | 2090-1283 |
Licença: | This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Fonte: Cholesterol <http://www.hindawi.com/journals/cholesterol/2013/754580/>. Acesso em: 20 jan. 2015. |
Aparece nas coleções: | DENCS - Artigos publicados em periódicos |
Arquivos associados a este item:
Arquivo | Descrição | Tamanho | Formato | |
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ARTIGO_LeishmaniaMajorSelf.pdf | 3,87 MB | Adobe PDF | Visualizar/Abrir |
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