Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/handle/123456789/4674
Title: Association between nutritional status, C-reactive protein, adiponectin and HOMA-AD in Brazilian children.
Other Titles: Asociación entre estado nutricional, proteína c-reactiva, adiponectina y homa-ad en niños brasileños.
Authors: Domingos, Ana Luiza Gomes
Coelho, George Luiz Lins Machado
Volp, Ana Carolina Pinheiro
Oliveira, Fernando Luiz Pereira de
Caldas, Ivo Santana
Freitas, Silvia Nascimento de
Keywords: Inflammation
Child
Insulin resistance
Obesidad
Marcadores biológicos
Issue Date: 2014
Citation: DOMINGOS, A. L. G. et al. Association between nutritional status, C-reactive protein, adiponectin and HOMA-AD in Brazilian children. Nutrición Hospitalaria, v. 30, p. 66-74, 2014. Disponível em: <http://www.aulamedica.es/nh/pdf/7322.pdf>. Acesso em: 08 nov. 2014.
Abstract: Introduction: In children, the presence of obesity is a major risk factor for the occurrence of cardiovascular diseases on the adulthood. Objective: To evaluate the association of anthropometry, body composition, clinical variables and biochemical profile with C-reactive protein and adiponectin levels, and insulin resistance in children in the municipality of Nova Era, Brazil. Methods: Nested case-control study following a crosssectional study. We evaluated 178 children, 57 of them classified as obese and 121 as normal-weight from a population of 1024 schoolchildren 6 to 10 years old: Blood samples were collected after 12-hour fast to obtain serum and plasma. We collected anthropometric and body composition measures, systolic and diastolic blood pressure data. Sexual maturation was assessed according to the stage of sexual development. We performed Student’s t-test, Mann-Whitney U test, Pearson’s correlation, Spearman’s test and multiple linear regression analysis. Independent variables with p < 0.05 were included in the multiple regression model. Residual analysis was performed to assess model validity. Results: Among obese children, C-reactive protein levels were associated with triacylglycerol levels and body fat percentage estimated by skinfold thickness (R2 adjusted = 27.6%, p < 0.001). Adiponectin was associated with HOMA-IR, HOMAAD and body fat percentage estimated by skinfold thickness (R2 adjusted = 75.5%, p < 0.001). HOMA-AD index was associated with HOMA-IR, adiponectin, systolic blood pressure and weight (R2 adjusted = 90.7%, p < 0.001). Conclusion: Significant associations were found between body composition, anthropometry, clinical variables, biochemical profile and adiponectin and C-reactive protein levels and insulin resistance in obese and normal-weight children.
metadata.dc.description.abstracten: Introducción: En niños, la obesidad es um factor de riesgo para enfermedades cardiovasculares en la edad adulta. Objetivos: Asociaciar la antropometría, composición corporal, variables clínicas y bioquímicas con la proteína C reactiva (PCR), adiponectina y resistencia a la insulina en niños de Nova Era, Brasil. Métodos: Estudio de casos y controles anidado en un transversal. Se evaluaron 178 niños, 57 obesos y 121 eutróficos en una población de 1.024 escolares de 6 a 10 años. Las muestras de sangre se recogieron después de 12 horas de ayuno. Recogimos las medidas antropométricas, de composición corporal y presión arterial. La madurez sexual fue evaluada de acuerdo con el desarrollo sexual. Se realizo las pruebas t de Student y U de MannWhitney, las correlaciones de Pearson y Spearman y el análisis de regresión lineal múltiple. Se incluyeron en el modelo de regresión, las variables independientes con p < 0,05. Se realizo el análisis residual para evaluar la validez del modelo. Resultados: Entre los niños obesos, los niveles de PCR se asociaron con los triglicéridos y el porcentaje de grasa corporal (%GC) estimada por los pliegues cutáneos (R2 ajustado = 27,6%, p < 0,001). La adiponectina se asoció con HOMA-IR, HOMA-AD y % GC estimada por los pliegues cutáneos (R2 ajustado = 75,5%, p < 0,001). El HOMA-AD se asoció con HOMA-IR, adiponectina, presión arterial sistólica y peso (R2 ajustado = 90,7%, p < 0,001). Conclusiones: Se encontraron asociaciones entre la composición corporal, antropometría, variables clínicas, perfil bioquímico, adiponectina, PCR y la resistencia a la insulina en niños obesos y eutróficos.
URI: http://www.repositorio.ufop.br/handle/123456789/4674
metadata.dc.identifier.doi: https://doi.org/10.3305/nh.2014.30.1.7322
ISSN: 0212-1611
metadata.dc.rights.license: Todo o conteúdo do periódico Nutricion Hospitalaria, exceto onde identificado, está sob uma licença Creative Commons que permite copiar, distribuir e transmitir o trabalho em qualquer suporte ou formato desde que sejam citados o autor e o licenciante. Não permite o uso para fins comerciais nem a adaptação. Fonte: Nutricion Hospitalaria <http://scielo.isciii.es/scielo.php?script=sci_serial&pid=0212-1611>. Acesso em: 25 jun. 2019.
Appears in Collections:DENCS - Artigos publicados em periódicos

Files in This Item:
File Description SizeFormat 
ARTIGO_AssociationBetweenNutritional.pdf129,23 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.