Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/handle/123456789/4638
Title: Altered renal response to acute volume expansion in transgenic rats harboring the human tissue kallikrein gene.
Authors: Passaglio, Kátia Tomagnini
Baltatu, Ovidiu
Machado, Raquel do Pilar
Reis, Adelina Martha dos
Pesquero, João Bosco
Bader, Michael
Santos, Robson Augusto Souza dos
Keywords: Kinins
Transgenic rats
Human genes
Issue Date: 2005
Citation: PASSAGLIO, K. T. et al. Altered renal response to acute volume expansion in transgenic rats harboring the human tissue kallikrein gene. Regulatory Peptides, v. 124, p. 127-135, 2005. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0167011504002435>. Acesso em: 08 nov. 2014.
Abstract: The renal response to acute volume expansion was investigated in transgenic (TGR) rats harboring the human tissue kallikrein gene. After a primer injection of 0.9% NaCl (3 ml/100 g, i.v), Sprague–Dawley (SD) or TGR rats received a continuous infusion of 0.9% NaCl (15 Al/ 100 g/min, i.a.) through a catheter placed into the carotid artery. Acute volume expansion was produced by a second injection of 0.9% NaCl (2 ml/100 g, i.v.) 65 min after the first injection. Plasma vasopressin (AVP) and atrial natriuretic peptide (ANP) concentration was measured before and within 10 min of volume expansion. TGR animals presented a blunted response to acute volume expansion evidenced by an attenuated increase in total and fractional water and sodium excretion. Before or after volume expansion, plasma AVP and ANP did not differ between SD and TGR. Pre-treatment with the BK-B2 antagonist HOE-140 (7.5 Ag/100 g. i.a) partially improved the renal response of TGRs and severely blunted the response in SD rats. These data show that TGR (hKLK1) rats have an impaired renal response to acute volume expansion that can not be accounted for by changes in the release of AVP or ANP.
URI: http://www.repositorio.ufop.br/handle/123456789/4638
metadata.dc.identifier.doi: https://doi.org/10.1016/j.regpep.2004.07.008
ISSN: 0167-0115
metadata.dc.rights.license: O periódico Regulatory Peptides concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3547120041852.
Appears in Collections:DECBI - Artigos publicados em periódicos

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