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Title: Infection with Leishmania major induces interleukin-12 production in vivo.
Authors: Vieira, Leda Quercia
Hondowicz, Brian D.
Afonso, Luís Carlos Crocco
Wysocka, Maria
Trinchieri, Giorgio
Scott, Phillip
Issue Date: 1994
Citation: VIEIRA, L. Q. et al. Infection with Leishmania major induces interleukin-12 production in vivo. Immunology Letters, v. 40, p. 157-161, 1994. Disponível em: <>. Acesso em: 08 nov. 2014.
Abstract: Experimental infections of mice with the protozoan parasite Leishmania major provide an excellent model for defining the conditions required for generation of CD4 ÷ Thl and Th2 cells in vivo. Since interleukin-12 (IL-12) has been implicated in the development of Thl cells, we investigated whether L. major stimulates IL-12 production in vitro or in vivo. Surprisingly, macrophages cultured in vitro failed to produce IL-12 following L. major infection. In contrast, lymph node cells from C3H mice infected for 2 days with L. major produced elevated levels of IL-12. In order to determine if the inability to stimulate IL-12 production was limited to in vitro infections, we infected macrophages in vivo by inoculating L. major into the peritoneal cavity. Peritoneal cells isolated 24 h later exhibited a significant increase in the number of cells producing IL-12. In addition, supernatants harvested from these cells following culture contained elevated levels of IL-12. These data indicate that L. major infection induces increased IL-12 production in mice.
ISSN: 0165-2478
metadata.dc.rights.license: O periódico Immunology Letters concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3530901220850.
Appears in Collections:DECBI - Artigos publicados em periódicos

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