Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/jspui/handle/123456789/4617
Title: Purification, amino-acid sequence and partial characterization of two toxins with anti-insect activity from the venom of the South American scorpion Tityus bahiensis (Buthidae).
Authors: Pimenta, Adriano Monteiro de Castro
Eauclaire, Marie France Martin
Rochat, Hervé
Figueiredo, Suely Gomes de
Kalapothakis, Evanguedes
Afonso, Luís Carlos Crocco
Lima, Maria Elena de
Keywords: Tityus bahiensis
Toxin
Anti-insect activity
Three-dimensional models
Issue Date: 2001
Citation: PIMENTA, A. M. de C. et al. Purification, amino-acid sequence and partial characterization of two toxins with anti-insect activity from the venom of the South American scorpion Tityus bahiensis (Buthidae). Toxicon, v. 39, p. 1009-1019, 2001. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0041010100002403>. Acesso em: 08 nov. 2014.
Abstract: We report here the isolation by a two-step chromatographic procedure of two new toxins from the South American scorpion Tityus bahiensis. Their amino-acid sequences and some of their biological features were established. The two toxins have different biological properties. Toxin TbIT-I had almost no activity or pharmacological effects in vertebrate tissues whereas it was lethal to house ¯ies (LD50 80.0 ng/house ¯y). In contrast, Tb2-II was active against both mammals (intracerebroventricular injection of 100 ng/mouse was lethal) and insects (LD50 40.0 ng/house ¯y). The amino-acid sequences of these toxins were established and found to be similar (60±95%) to previously described b-toxins from the Tityus genus. Based on the available comparative information, this study attempts identify possible structure±function relationships that may be responsible for the differences in bioactivity displayed by these toxins.
URI: http://www.repositorio.ufop.br/handle/123456789/4617
metadata.dc.identifier.doi: https://doi.org/10.1016/S0041-0101(00)00240-3
ISSN: 0041-0101
metadata.dc.rights.license: O periódico Toxicon concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3530901439097.
Appears in Collections:DECBI - Artigos publicados em periódicos

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