Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/handle/123456789/4328
Title: Kinetics of cell migration to the dermis and hypodermis in dogs vaccinated with antigenic compounds of Leishmania braziliensis plus saponin.
Authors: Souza, Juliana Vitoriano de
Reis, Alexandre Barbosa
Moreira, Nádia das Dores
Giunchetti, Rodolfo Cordeiro
Oliveira, Rodrigo Corrêa de
Carneiro, Cláudia Martins
Keywords: Inflammation and cell migration
Canine visceral leishmaniasis
Innate-immune response
Vaccine
Saponin
Issue Date: 2008
Citation: SOUZA, J. V. et al. Kinetics of cell migration to the dermis and hypodermis in dogs vaccinated with antigenic compounds of Leishmania braziliensis plus saponin. Vaccine, Guildford, v. 26, p. 3922-3931, 2008. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0264410X08005537>. Acesso em: 15 ago. 2014.
Abstract: The search for new immunobiologicals against canine visceral leishmaniasis (CVL) has intensified in the last decade. However, it still remains to be elucidated that mechanisms of the innate immune response in situ after immunization (a.i.). The aim of this study was to investigate the kinetics of cell migration in the skin dogs with distinct antigenic compounds of the LBSap vaccine. Our major findings indicated that saponin adjuvant alone or combined with Leishmania braziliensis antigen induced strong local acute inflammatory reaction. However, these reactions not progressed to ulcerated lesions. Overall, the cell profile found in Sap and LBSap was composed of neutrophils, lymphocytes and eosinophils. There was also increased production of iNOS in Sap and LBSap groups. Thus, we can conclude that dogs immunized by LBSap and the saponin adjuvant elicited a potential innate-immune activations status compatible with effective control of the resistance to infection by Leishmania and contributing to a better understanding of the innate-immunity events induced by the LBSap vaccine.
URI: http://www.repositorio.ufop.br/handle/123456789/4328
metadata.dc.identifier.doi: https://doi.org/10.1016/j.vaccine.2008.04.084
ISSN: 0264-410X
metadata.dc.rights.license: O periódico Vaccine concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3446031456908.
Appears in Collections:DEACL - Artigos publicados em periódicos

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