Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/jspui/handle/123456789/4313
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dc.contributor.authorNicolato, Roney Luiz de Carvalho-
dc.contributor.authorAbreu, Raquel Trópia de-
dc.contributor.authorRoatt, Bruno Mendes-
dc.contributor.authorSoares, Rodrigo Dian de Oliveira Aguiar-
dc.contributor.authorReis, Levi Eduardo Soares-
dc.contributor.authorCarvalho, Maria das Graças-
dc.contributor.authorCarneiro, Cláudia Martins-
dc.contributor.authorGiunchetti, Rodolfo Cordeiro-
dc.contributor.authorBouillet, Leoneide Érica Maduro-
dc.contributor.authorLemos, Denise da Silveira-
dc.contributor.authorVital, Wendel Coura-
dc.contributor.authorReis, Alexandre Barbosa-
dc.date.accessioned2015-01-21T18:20:27Z-
dc.date.available2015-01-21T18:20:27Z-
dc.date.issued2013-
dc.identifier.citationNICOLATO, R. de C. et al. Clinical forms of canine visceral Leishmaniasis in naturally Leishmania infantum – infected dogs and related myelogram and hemogram changes. Plos One, v. 8, p. e82947, 2013. Disponível em: <http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0082947>. Acesso em: 12 ago. 2014.pt_BR
dc.identifier.issn1932-6203-
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/4313-
dc.description.abstractHematological analysis has limited applications for disease diagnosis in Leishmania infantum–infected dogs, but it can be very important in evaluating the clinical forms of the disease and in understanding the evolution of canine visceral leishmaniasis (CVL) pathogenesis. Recently, we demonstrated that alterations in leucopoiesis and erythropoiesis are related to clinical status and bone marrow parasite density in dogs naturally infected by L. infantum. To further characterize these alterations, we evaluated the association between the hematological parameters in bone marrow and peripheral blood alterations in groups of L. infantum–infected dogs: asymptomatic I (AD-I: serum negative/PCR+), asymptomatic II (AD-II: serum positive), oligosymptomatic (OD), and symptomatic (SD). Results were compared with those from noninfected dogs (NID). The SD group was found to present a decrease in erythropoietic lineage with concomitant reductions in erythrocytes, hemoglobin, and hematocrit parameters, resulting in anemia. The SD group also had increased neutrophils and precursors and decreased band eosinophils and eosinophils, leading to peripheral blood leucopenia. In the AD-II group, lymphocytosis occurred in both the peripheral blood and the bone marrow compartments. The SD group exhibited lymphocytosis in the bone marrow, with lymphopenia in the peripheral blood. In contrast, the AD-I group, showed no significant changes suggestive of CVL, presenting normal counts in bone marrow and peripheral blood. Our results showed for the first time that important changes in hematopoiesis and hematological parameters occur during ongoing CVL in naturally infected dogs, mainly in symptomatic disease. Taken together, our results based on myelogram and hemogram parameters enable better understanding of the pathogenesis of the anemia, lymphocytosis, and lymphopenia, as well as the leucopenia (eosinopenia and monocytopenia), that contribute to CVL prognosis.pt_BR
dc.language.isoen_USpt_BR
dc.subjectLeishmania infantumpt_BR
dc.subjectCanine visceral leishmaniasispt_BR
dc.titleClinical forms of canine visceral Leishmaniasis in naturally Leishmania infantum – infected dogs and related myelogram and hemogram changes.pt_BR
dc.typeArtigo publicado em periodicopt_BR
dc.rights.licenseOs trabalhos publicados na Plos one estão sob Licença Creative Commons que permite copiar, distribuir e transmitir o trabalho, desde que sejam citados o autor e licenciante. Não permite o uso para fins comerciais nem a adaptação. Fonte: Plos one <https://www.plos.org/open-access>. Acesso em: 03 jan. 2017.pt_BR
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0082947-
Appears in Collections:DEACL - Artigos publicados em periódicos

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