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dc.contributor.authorVital, Wendel Coura-
dc.contributor.authorReis, Alexandre Barbosa-
dc.contributor.authorFausto, Maria Arlene-
dc.contributor.authorLeal, Gleisiane Gomes de Almeida-
dc.contributor.authorMarques, Marcos José-
dc.contributor.authorVeloso, Vanja Maria-
dc.contributor.authorCarneiro, Mariângela-
dc.identifier.citationVITAL, W. C. et al. Risk factors for seroconversion by Leishmania infantum in a cohort of dogs from an endemic area of Brazil. Plos One, v. 8, p. e71833, 2013. Disponível em: <>. Acesso em: 12 ago. 2014.pt_BR
dc.description.abstractVisceral leishmaniasis (VL) has recently emerged in various urban and peri-urban areas of Brazil and other countries. Understanding the urbanization of VL requires identification of risk factors associated with human and canine infection. To determine the predictors of risk for canine VL, a survey was conducted of 1,443 dogs, from which a cohort was selected (n = 455) and evaluated for approximately 26 months. Serology was conducted with two enzyme-linked immunosorbent assays (ELISA): one conducted in the Laboratory of Zoonosis of the Belo Horizonte Health Department (LZOON) and the other in the Laboratory of Immunopathology of the Federal University of Ouro Preto (LIMP). A molecular diagnostic method (PCR–restriction fragment length polymorphism) and a structured questionnaire were also used. To identify the factors associated with seroconversion, two time-dependent Cox regression models were performed with different sensitivities (model 1, seroconversion by ELISA/LZOON; model 2, seroconversion by ELISA/LIMP). The overall incidences of seroconversion were 6.5/1000 dogs-months and 11.2/1000 dogs-months for ELISA/LZOON and ELISA/LIMP, respectively. Increased risk of seroconversion was associated with short fur (model 1: hazard ratio [HR] 1.9), the presence of dry leaves (model 1: HR 2.8) or manure (model 1: HR 3.5) in the backyard, dogs sleeping predominantly in the backyard (model 2: HR 2.1), the presence of symptoms (model 2: HR 2.0), and positive molecular results during follow-up (model 2: HR 1.5). Decreased risk was associated with insecticide spraying in the house (model 2: HR 0.5). These results indicate that morevulnerable domiciles, certain dog behaviors, lack of vector control measures, and positive molecular results were associated with the occurrence of canine VL. Furthermore, it is important to emphasize that PCR-positive dogs should be monitored, owing to the possibility of seroconversion. Identifying risk factors for seroconversion in dogs is crucial for developing adequate strategies for VL prevention and control.pt_BR
dc.subjectLeishmania infantumpt_BR
dc.subjectCanine visceral leishmaniasispt_BR
dc.titleRisk factors for seroconversion by Leishmania infantum in a cohort of dogs from an endemic area of Brazil.pt_BR
dc.typeArtigo publicado em periodicopt_BR
dc.rights.licenseOs trabalhos publicados na Plos one estão sob Licença Creative Commons que permite copiar, distribuir e transmitir o trabalho, desde que sejam citados o autor e licenciante. Não permite o uso para fins comerciais nem a adaptação. Fonte: Plos one <>. Acesso em: 03 jan. 2017.pt_BR
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