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Title: Profile of anti-Leishmania antibodies related to clinical picture in canine visceral leishmaniasis.
Authors: Freitas, José Cláudio Carneiro de
Lopes Neto, Belarmino Eugênio
Abreu, Cyntia Rafaelle Amaral de
Vital, Wendel Coura
Braga, Samuel Leôncio
Reis, Alexandre Barbosa
Pinheiro, Diana Célia Sousa Nunes
Keywords: Leishmania antibodies
Canine visceral leishmaniasis
Clinical pictures
Leishmania chagasi
Issue Date: 2012
Citation: FREITAS, J.C. C. de et al. Profile of anti-Leishmania antibodies related to clinical picture in canine visceral leishmaniasis. Research in Veterinary Science, v. 93, p. 705-709, 2012. Disponível em: <>. Acesso em: 13 ago. 2014.
Abstract: This research investigated the profile of anti-Leishmania antibodies in different clinical forms of canine visceral leishmaniasis (CVL). Naturally infected dogs were divided into two groups: subclinical dogs (SD, n = 10) and clinical dogs (CD, n = 68). Non-infected dogs (ND, n = 7) comprised the negative control group. The humoral response was evaluated by the profile of total IgG, IgG1, IgG2, IgM, IgA and IgE, determined by ELISA. Infected animals showed increased levels of total IgG, IgA and IgE in addition to IgG1 and IgG2 in groups SD and CD, when compared with group ND. Furthermore, it was observed that IgG2 and IgM were correlated with symptomatology, while total IgG, IgG1 and IgA were negatively correlated and IgE showed no correlation. It follows that serum levels of IgG2 anti-Leishmania are correlated with typical clinical signs of disease. Furthermore the determination of specific anti-Leishmania antibodies could be an important tool in monitoring CVL clinical picture.
ISSN: 0034-5288
metadata.dc.rights.license: O periódico Research in Veterinary Science concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3442010848687.
Appears in Collections:DEACL - Artigos publicados em periódicos

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