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Title: Low levels of vasoactive intestinal peptide are associated with Chagas disease cardiomyopathy.
Authors: Corrêa, Marielle Valério
Rocha, Manoel Otávio da Costa
Sousa, Giovane Rodrigo de
Nunes, Maria do Carmo Pereira
Gollob, Kenneth John
Dutra, Walderez Ornelas
Menezes, Cristiane Alves da Silva
Keywords: Peptídeo intestinal
Intestinal peptide
Chagas disease
Issue Date: 2013
Citation: CORRÊA, M. V. et al. Low levels of vasoactive intestinal peptide are associated with Chagas disease cardiomyopathy. Human Immunology, v. 74, p. 1375-1381, 2013. Disponível em: <>. Acesso em: 08 nov. 2014.
Abstract: The interconnection between immune and neuroendocrine systems influences regulation of inflammatory responses. The possible relevance that this integrative response may have during the course of Chagas disease remains poorly characterized. In this context, our study was designed to determine the expression of vasoactive intestinal peptide (VIP), a neuropeptide with anti-inflammatory properties, in blood from the indeterminate and cardiac polarized forms of Chagas disease. Moreover, we determined whether the differential expression of VIP is associated with the development of cardiomyopathy in individuals infected with Trypanosoma cruzi. Finally, we analyzed gene polymorphisms of VIP receptors, VPAC1 and VPAC2, and performed correlation analysis of these polymorphisms with the different clinical forms of Chagas disease. Our results demonstrated that low plasma levels of VIP were associated with the cardiac morbidity in Chagas disease. Accordingly, correlation analysis showed that low plasma levels of VIP were associated with worse cardiac function, as determined by left ventricular ejection fraction and left ventricular diastolic diameter values. Polymorphism analysis showed a significant association between VPAC1 and the indeterminate form of Chagas disease development. Our data indicate that VIP expression and its receptors’ polymorphism may be important in determining susceptibility to progression from mild to severe forms of Chagas disease.
ISSN: 0198-8859
metadata.dc.rights.license: O periódico Human Immunology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3520371269386.
Appears in Collections:DECBI - Artigos publicados em periódicos

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