Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/handle/123456789/4185
Title: Trypanosoma cruzi infection alters glucose metabolism at rest and during exercise without modifying the morphology of pancreatic islets in rats.
Authors: Novaes, Rômulo Dias
Gonçalves, Reggiani Vilela
Penitente, Arlete Rita
Silva, André Talvani Pedrosa da
Neves, Clóvis Andrade
Natali, Antônio José
Maldonado, Izabel Regina dos Santos Costa
Keywords: Chagas disease
Glucose metabolism
Pancreas
Pathology
Exercise
Issue Date: 2012
Citation: NOVAES, R. D. et al. Trypanosoma cruzi infection alters glucose metabolism at rest and during exercise without modifying the morphology of pancreatic islets in rats. Pathology, Research and Practice, v. 208, p. 480-488, 2012. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0344033812001549>. Acesso em: 08 nov. 2014.
Abstract: This study investigated the effects of Trypanosoma cruzi infection on pancreatic morphology and glucose metabolism at rest and during exercise. Wistar rats were randomized into control (CG = 10) and infected (IG = 10) groups. The IG animals were inoculated with T. cruzi Y strain (300,000 trypomastigotes/50 g). After 9 weeks, the animals were subjected to glucose (OGTT) and insulin (ITT) tolerance tests and a treadmill running protocol. Blood glucose, lactate and time to fatigue were determined. After euthanasia, the pancreases were removed for morphological and biochemical analyses. The IG presented abnormal glucose kinetics in OGTT and a similar glucose curve in ITT compared to the CG. During the exercise test, the IG showed anticipation of time to fatigue. At the point of fatigue, no difference was found in blood glucose and lactate between the groups. There was a significant correlation between lactate levels and the time to fatigue. The IG presented marked pancreatic inflammation, fibrosis and protein oxidation. The number of _ cells in the IG animals was not reduced. T. cruzi infection impaired pancreas morphology and glucose metabolism at rest and during exercise in rats, which could constitute an additional mechanism in the induction of exercise intolerance in Chagas’ disease.
URI: http://www.repositorio.ufop.br/handle/123456789/4185
metadata.dc.identifier.doi: https://doi.org/10.1016/j.prp.2012.05.016
ISSN: 0344-0338
metadata.dc.rights.license: O periódico Pathology - Research and Practice concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3517691008073.
Appears in Collections:DECBI - Artigos publicados em periódicos

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