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Title: Vildagliptin ameliorates oxidative stress and pancreatic beta cell destruction in type 1 diabetic rats.
Authors: Ávila, Danielle de Lima
Araújo, Glaucy Rodrigues de
Silva, Maísa
Miranda, Pedro Henrique de Amorim
Diniz, Mirla Fiuza
Pedrosa, Maria Lúcia
Silva, Marcelo Eustáquio
Lima, Wanderson Geraldo de
Costa, Daniela Caldeira
Keywords: Pancreas
Oxidative stress
Issue Date: 2013
Citation: ÁVILA, D. L. et al. Vildagliptin ameliorates oxidative stress and pancreatic beta cell destruction in type 1 diabetic rats. Archives of Medical Research, p. 194-202, 2013. Disponível em: <>. Acesso em: 08 nov. 2014.
Abstract: Background and Aims. It is believed that oxidative stress plays a role in the pathogenesis of diabetes mellitus. Several strategies have been developed with the objective of minimizing diabetic complications. Among these, inhibitors of dipeptidyl peptidase-IV (DPP-IV), which act by blocking degradation of incretin hormones, glucagon-like peptide hormone (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), have been the focus of many studies. It is known that, among the effects of incretins, we highlight its insulinotropic and cytoprotective effects on pancreatic b-cells. The objective of this study was to evaluate the possible protective effects of treatment with vildagliptin, a DPP-IV inhibitor, in b-cells in an experimental model of type 1 diabetes induced by streptozotocin (STZ). Methods. Rats were treated for 4 weeks with vildagliptin at concentrations of 5 and 10 mg/kg. In order to observe the pancreatic damage and the possible protective effects of vildagliptin treatment, we measured stress markers TBARS and protein carbonyl, antioxidant enzymes SOD and catalase, and analyzed pancreatic histology. Results. The treatment was effective in modulating stress in pancreatic tissue, both by reducing levels of stress markers as well as by increasing activity of SOD and catalase. After analyzing the pancreatic histology, we found that vildagliptin was also able to preserve islets and pancreatic b-cells, especially at the concentration of 5 mg/kg. Conclusion. Thus, our results suggest that vildagliptin ameliorates oxidative stress and pancreatic beta cell destruction in type 1 diabetic rats. However, to evaluate the real potential of this medication in type 1 diabetes, further studies are needed.
ISSN: 0188-4409
metadata.dc.rights.license: O periódico Archives of Medical Research concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3520371332132.
Appears in Collections:DECBI - Artigos publicados em periódicos

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