Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/handle/123456789/4027
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dc.contributor.authorMiyamoto, Cláudia Tiemi-
dc.contributor.authorGomes, Mônica Lúcia-
dc.contributor.authorMarangon, Aline Vansan-
dc.contributor.authorAraújo, Silvana Marques de-
dc.contributor.authorBahia, Maria Terezinha-
dc.contributor.authorMartins Filho, Olindo Assis-
dc.contributor.authorLana, Marta de-
dc.contributor.authorToledo, Max Jean de Ornelas-
dc.date.accessioned2014-11-20T17:06:53Z-
dc.date.available2014-11-20T17:06:53Z-
dc.date.issued2008-
dc.identifier.citationMIYAMOTO, C. T. et al. Usefulness of the polymerase chain reaction for monitoring cure of mice infected with different Trypanosoma cruzi clonal genotypes following treatment with benznidazole. Experimental Parasitology, v. 120, p. 45-49, 2008. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0014489408001215>. Acesso em: 28 ago. 2014.pt_BR
dc.identifier.issn0014-4894-
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/4027-
dc.description.abstractThe capacity of the polymerase chain reaction (PCR) to detect the DNA of Trypanosoma cruzi was evaluated in 90 blood samples from BALB/c mice infected with T. cruzi cloned stocks of genotypes 19 and 20 (T. cruzi I) and 39 and 32 (T. cruzi II), and treated with benznidazole. The results from the fresh blood examination, hemoculture, and ELISA allowed to group the treated animals into: cured (TC), dissociated (DIS) and non-cured (NC). The PCR detected T. cruzi DNA in 50.9%, 58.3% and 100.0% of the samples from TC, DIS and NC mice, respectively. These DNA possibly derives from live T. cruzi or from recently lysed parasites, suggests that these animals are in fact not cured. The difference between the PCR results and results obtained using other techniques was statistically significant and independent of the parasite genotype. The PCR described has therefore potential to be used in cure control of treated patients.pt_BR
dc.language.isoen_USpt_BR
dc.subjectTrypanosoma cruzipt_BR
dc.subjectBenznidazolept_BR
dc.subjectPolymerase chain reactionpt_BR
dc.titleUsefulness of the polymerase chain reaction for monitoring cure of mice infected with different Trypanosoma cruzi clonal genotypes following treatment with benznidazole.pt_BR
dc.typeArtigo publicado em periodicopt_BR
dc.rights.licenseO periódico Experimental Parasitology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3462661422634.pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.exppara.2008.04.018-
Appears in Collections:DEACL - Artigos publicados em periódicos

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