Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/handle/123456789/3967
Title: Antigenic extracts of Leishmania braziliensis and Leishmania amazonensis associated with saponin partially protects BALB/c mice against Leishmania chagasi infection by suppressing IL-10 and IL-4 production.
Authors: Grenfell, Rafaella Fortini Queiroz
Silva, Eduardo de Almeida Marques da
Testasicca, Miriam Conceição de Souza
Coelho, Eduardo Antônio Ferraz
Fernandes, Ana Paula
Afonso, Luís Carlos Crocco
Rezende, Simone Aparecida
Keywords: Vaccine
Leishmania chagasi
Leishmania braziliensis
Leishmania amazonensis
Issue Date: 2010
Citation: GRENFELL, R. F. Q. et al. Antigenic extracts of Leishmania braziliensis and Leishmania amazonensis associated with saponin partially protects BALB/c mice against Leishmania chagasi infection by suppressing IL-10 and IL-4 production. Memórias do Instituto Oswaldo Cruz, v. 105, p. 818-822, 2010. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762010000600015&lng=en&nrm=iso&tlng=en>. Acesso em: 28 ago. 2014.
Abstract: This study evaluated two vaccine candidates for their effectiveness in protecting BALB/c mice against Leishma¬nia chagasi infection. These immunogenic preparations were composed of Leishmania amazonensis or Leishmania braziliensis antigenic extracts in association with saponin adjuvant. Mice were given three subcutaneous doses of one of these vaccine candidates weekly for three weeks and four weeks later challenged with promastigotes of L. chagasi by intravenous injection. We observed that both vaccine candidates induced a significant reduction in the parasite load of the liver, while the L. amazonensis antigenic extract also stimulated a reduction in spleen parasite load. This protection was associated with a suppression of both interleukin (IL)-10 and IL-4 cytokines by spleen cells in response to L. chagasi antigen. No change was detected in the production of IFN-γ. Our data show that these im-munogenic preparations reduce the type 2 immune response leading to the control of parasite replication.
URI: http://www.repositorio.ufop.br/handle/123456789/3967
metadata.dc.identifier.doi: http://dx.doi.org/10.1590/S0074-02762010000600015
ISSN: 0074-0276
metadata.dc.rights.license: O periódico Memórias do Instituto Oswaldo Cruz permite que o Repositório Institucional da Universidade Federal de Ouro Preto (UFOP) deposite uma cópia eletrônica dos artigos publicados por esse periódico  em que ao menos um dos autores faça parte da comunidade cientifica da UFOP. Fonte: Licença concedida mediante prenchimento de formulário enviado no dia 12 dez. 2013.
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