Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/handle/123456789/3866
Title: Nanotechnology applied to the treatment of malaria.
Authors: Magalhães, Nereide Stela Santos
Mosqueira, Vanessa Carla Furtado
Keywords: Malaria
Nanocarriers
Liposomes
Nanocapsules
Antimalarials
Issue Date: 2010
Citation: MAGALHÃES, N. S. S; MOSQUEIRA V. C. F. Nanotechnology applied to the treatment of malaria. Advanced Drug Delivery Reviews, v. 62, p. 560-575, 2010. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0169409X09003652>. Acesso em: 20 ago. 2014.
Abstract: Despite the fact that we live in an era of advanced technology and innovation, infectious diseases, like malaria, continue to be one of the greatest health challenges worldwide. The main drawbacks of conventional malaria chemotherapy are the development of multiple drug resistance and the non-specific targeting to intracellular parasites, resulting in high dose requirements and subsequent intolerable toxicity. Nanosized carriers have been receiving special attention with the aim of minimizing the side effects of drug therapy, such as poor bioavailability and the selectivity of drugs. Several nanosized delivery systems have already proved their effectiveness in animal models for the treatment and prophylaxis of malaria. A number of strategies to deliver antimalarials using nanocarriers and the mechanisms that facilitate their targeting to Plasmodium spp.-infected cells are discussed in this review. Taking into account the peculiarities of malaria parasites, the focus is placed particularly on lipid-based (e.g., liposomes, solid lipid nanoparticles and nano and microemulsions) and polymer-based nanocarriers (nanocapsules and nanospheres). This review emphasizes the main requirements for developing new nanotechnology-based carriers as a promising choice in malaria treatment, especially in the case of severe cerebral malaria.
URI: http://www.repositorio.ufop.br/handle/123456789/3866
metadata.dc.identifier.doi: https://doi.org/10.1016/j.addr.2009.11.024
ISSN: 0169-409X
metadata.dc.rights.license: O periódico Advanced Drug Delivery Reviews concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença:3460320566734.
Appears in Collections:DEFAR - Artigos publicados em periódicos

Files in This Item:
File Description SizeFormat 
ARTIGO_NanotechnologyAppliedTreatment.pdf1,34 MBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.