Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/handle/123456789/3832
Title: SLCO1B1 RS4149056 polymorphism associated with statin-induced myopathy is differently distributed according to ethnicity in the Brazilian general population : amerindians as a high risk ethnic group.
Authors: Santos, Paulo Caleb Júnior de Lima
Soares, Renata A. G.
Nascimento Neto, Raimundo Marques do
Coelho, George Luiz Lins Machado
Mill, José Geraldo
Krieger, José Eduardo
Pereira, Alexandre da Costa
Keywords: Statins
Myopathy
Amerindian
Pharmacogenetic
Issue Date: 2011
Citation: SANTOS, P. C. J. M. et al. SLCO1B1 RS4149056 polymorphism associated with statin-induced myopathy is differently distributed according to ethnicity in the Brazilian general population: amerindians as a high risk ethnic group. BMC Medical Genetics, v. 12, p. 136, 2011. Disponível em: <http://www.biomedcentral.com/1471-2350/12/136>. Acesso em: 01 set. 2014.
Abstract: Background: Recent studies reported the association between SLCO1B1 polymorphisms and the development of statin-induced myopathy. In the scenario of the Brazilian population, being one of the most heterogeneous in the world, the main aim here was to evaluate SLCO1B1 polymorphisms according to ethnic groups as an initial step for future pharmacogenetic studies. Methods: One hundred and eighty-two Amerindians plus 1,032 subjects from the general urban population were included. Genotypes for the SLCO1B1 rs4149056 (c.T521C, p.V174A, exon 5) and SLCO1B1 rs4363657 (g.T89595C, intron 11) polymorphisms were detected by polymerase chain reaction followed by high resolution melting analysis with the Rotor Gene 6000® instrument. Results: The frequencies of the SLCO1B1 rs4149056 and rs4363657 C variant allele were higher in Amerindians (28.3% and 26.1%) and were lower in African descent subjects (5.7% and 10.8%) compared with Mulatto (14.9% and 18.2%) and Caucasian descent (14.8% and 15.4%) ethnic groups (p < 0.001 and p < 0.001, respectively). Linkage disequilibrium analysis show that these variant alleles are in different linkage disequilibrium patterns depending on the ethnic origin. Conclusion: Our findings indicate interethnic differences for the SLCO1B1 rs4149056 C risk allele frequency among Brazilians. These data will be useful in the development of effective programs for stratifying individuals regarding adherence, efficacy and choice of statin-type.
URI: http://www.repositorio.ufop.br/handle/123456789/3832
metadata.dc.identifier.doi: https://doi.org/10.1186/1471-2350-12-136
ISSN: 1471-2350
metadata.dc.rights.license: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Fonte: BMC Medical Genetics <http://www.biomedcentral.com/1471-2350/12/136>. Acesso em: 01 set. 2014.
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