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Title: Morphological aspects and immunophenotypic profiles of mammary carcinomas in benign-mixed tumors of female dogs.
Authors: Ribeiro, Gustavo Meirelles
Bertagnolli, Angélica Cavalheiro
Rocha, Rafael Malagoli
Cassali, Geovanni Dantas
Issue Date: 2012
Citation: RIBEIRO, G. V. et al. Morphological aspects and immunophenotypic profiles of mammary carcinomas in benign-mixed tumors of female dogs. Veterinary Medicine International, v. 2012, p. ID 432763, 2012. Disponível em: <>. Acesso em: 03 set. 2014.
Abstract: Carcinoma in benign-mixed tumor (CBMT) is common in the female canine mammary gland and comprises malignant epithelial between benign mesenchymal elements. This study investigated the morphological aspects of 29 CBMT and their immunophenotypical profiles, by using an immunohistochemistry panel based on five molecular markers—estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), cytokeratin 5 (CK5), and human epidermal growth factor receptor 1 (EGFR). From these, CBMT was classified into four subtypes: luminal A, luminal B, HER2-like, basallike, and normal. “In situ” and invasive carcinomatous components were analyzed and compared. Histological grade I carcinoma was observed in 16 cases (55.2%) of the tumors analyzed, grade II in 10 cases (34.5%), and grade III in three cases (10.3%). The invasive carcinomatous component has shown, more frequently, luminal A (12/29 cases, 41.4%), followed by basal-like phenotype (8/29 cases, 27.6%). There was high concordance between immunophenotypical profiles of the in situ and invasive carcinomatous components (kappa coefficient = 0.816,P < 0.001).We concluded that CBMT predominantly has features of low-grade neoplasms of malignancy. The various immunophenotypic profiles suggest the origin of these lesions in more than one cell type (luminal and myoepithelial).
ISSN: 2042-0048
metadata.dc.rights.license: This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Fonte: Veterinary Medicine International <>. Acesso em: 03 set. 2014.
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