Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/handle/123456789/3825
Title: Argyrophil cell density in the oxyntic mucosa is higher in female than in male morbidly obese patients.
Authors: Maksud, Fabiana Alves Nunes
Kakehasi, Adriana Maria
Barbosa, Alfredo José Afonso
Keywords: Argyrophil cells
Endocrine cells
Obesity
Gastric mucosa
Metabolic syndrome
Issue Date: 2013
Citation: MAKSUD, F. A. N; KAKEHASI, A. M.; BARBOSA, A. J. A. Argyrophil cell density in the oxyntic mucosa is higher in female than in male morbidly obese patients. Brazilian Journal of Medical and Biological Research, v. 46, p. 339-342, 2013. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000400339>. Acesso em: 01 set. 2014.
Abstract: Obesity is a multifactorial disorder often associated with many important diseases such as diabetes, hypertension and other metabolic syndrome conditions. Argyrophil cells represent almost the total population of endocrine cells of the human gastric mucosa and some reports have described changes of specific types of these cells in patients with obesity and metabolic syndrome. The present study was designed to evaluate the global population of argyrophil cells of the gastric mucosa of morbidly obese and dyspeptic non-obese patients. Gastric biopsies of antropyloric and oxyntic mucosa were obtained from 50 morbidly obese patients (BMI .40) and 50 non-obese patients (17 dyspeptic overweight and 33 lean individuals) and processed for histology and Grimelius staining for argyrophil cell demonstration. Argyrophil cell density in the oxyntic mucosa of morbidly obese patients was higher in female (238.68 ± 83.71 cells/mm2) than in male patients (179.31 ± 85.96 cells/mm2) and also higher in female (214.20 ± 50.38 cells/mm2) than in male (141.90 ± 61.22 cells/mm2) morbidly obese patients with metabolic syndrome (P = 0.01 and P = 0.02, respectively). In antropyloric mucosa, the main difference in argyrophil cell density was observed between female morbidly obese patients with (167.00 ± 69.30 cells/mm2) and without (234.00 ± 69.54 cells/mm2) metabolic syndrome (P = 0.001). In conclusion, the present results show that the number of gastric argyrophil cells could be under gender influence in patients with morbid obesity. In addition, gastric argyrophil cells seem to behave differently among female morbidly obese patients with and without metabolic syndrome.
URI: http://www.repositorio.ufop.br/handle/123456789/3825
metadata.dc.identifier.doi: http://dx.doi.org/10.1590/1414-431X20132609
ISSN: 1414-431X
metadata.dc.rights.license: Todo o conteúdo do periódico Brazilian Journal of Medical and Biological Research, exceto onde identificado, está sob uma licença Creative Commons 4.0 que permite copiar, distribuir e transmitir o trabalho em qualquer suporte ou formato desde que sejam citados o autor e o licenciante. Fonte: Brazilian Journal of Medical and Biological Research <http://www.scielo.br/scielo.php?script=sci_serial&pid=0100-879X&lng=en&nrm=iso>. Acesso em: 20 out. 2016.
Appears in Collections:DECPA - Artigos publicados em periódicos

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