Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/handle/123456789/3640
Title: Enhanced schistosomicidal efficacy of tartar emetic encapsulated in pegylated liposomes.
Authors: Melo, Alan Lane de
Barcellos, Neila Marcia Silva
Demicheli, Cynthia Peres
Frezard, Frederic Jean Georges
Keywords: Liposomes
Tartar emetic
Schistosomiasis
Antimony
Schistosoma mansoni
Issue Date: 2003
Citation: MELO, A. L. et al. Enhanced schistosomicidal efficacy of tartar emetic encapsulated in pegylated liposomes. International Journal of Pharmaceutics, v. 255, p. 227-230, 2003. Disponível em: <http://www.sciencedirect.com/science/article/pii/S037851730300125X>. Acesso em: 20 ago. 2014.
Abstract: The aim of the present study was to evaluate the ability of liposomes to improve the efficacy of tartar emetic (TA) against established Schistosoma mansoni infection. TA was used as a schistosomicidal drug model and both conventional liposomes (CL) and long-circulating pegylated liposomes (LCL) were evaluated. In the first experiment, TA, either free or encapsulated within CL or LCL, was given intraperitoneally (i.p.) as a single dose of 11 mg Sb/kg to mice experimentally infected with S. mansoni. Only the group treated with LCL showed a significant (55%) reduction in the worm burden, compared to the control groups (untreated or treated with empty LCL). In the second experiment, the efficacy of TA-containing LCL was evaluated at a higher dose (27 mg Sb/kg) by both subcutaneous (s.c.) and i.p. routes. Reduction levels of 67 and 82% were achieved by s.c. and i.p. routes, respectively. Strikingly, all mice survived to this high dose of antimony. This is in contrast with free TA that was lethal in 100% of mice at the same dose. The present work demonstrates that LCL reduce the acute toxicity of TA and effectively deliver this drug to S. mansoni during the late stages of parasite infection.
URI: http://www.repositorio.ufop.br/handle/123456789/3640
metadata.dc.identifier.doi: http://dx.doi.org/10.1590/S0100-40422012000600031
ISSN: 0378-5173
metadata.dc.rights.license: O periódico International Journal of Pharmaceutics concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3456621140408.
Appears in Collections:DEFAR - Artigos publicados em periódicos

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