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Title: Simvastatin assay and dissolution studies by feasible rp-hplc in tablets.
Authors: Marinho, Flávia Dias Marques
Santos, Amanda Leão dos
Soares, Cristina Duarte Vianna
Reis, Ilka Afonso
Zanon, José Carlos da Costa
Lima, Angélica Alves
Keywords: Simvastatin tablets
Dissolution studies
Issue Date: 2012
Citation: MARINHO, F. D. M. et al. Simvastatin assay and dissolution studies by feasible rp-hplc in tablets. Química Nova, v. 35, p. 1233-1238, 2012. Disponível em: <>. Acesso em: 20 ago. 2014.
Abstract: Commonly used HPLC acetonitrile solvent has been through a worldwide shortage with a cost increase in 2008 and 2009. In order to get around this situation, a method by RP-HPLC employing methanol and aqueous acid mobile phase was developed and validated to evaluate simvastatin. The quality control assay and dissolution studies of this lipid-lowering drug were performed in diluents methanol and 0.01 M phosphate buffer with 0.5% SDS, pH 7, respectively. Dissolution test aliquots did not go through sample treatment, as described in USP SIM tablets monograph by ultraviolet spectrophotometry. The proposed method is fast, simple, feasible and robust.
ISSN: 1678-7064
metadata.dc.rights.license: A Sociedade Brasileira de Química dá permissão à UFOP para reproduzir no RI/UFOP, uma cópia em formato eletrônico dos artigos completos, sem nenhuma edição e/ou modificação, publicados na revista Química Nova, que tenham como autores seus alunos e/ou professores. 17 set. 2013.
Appears in Collections:DEFAR - Artigos publicados em periódicos

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