Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/handle/123456789/3628
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dc.contributor.authorFrezard, Frederic Jean Georges-
dc.contributor.authorBarcellos, Neila Marcia Silva-
dc.contributor.authorSantos, Robson Augusto Souza dos-
dc.date.accessioned2014-09-09T18:23:23Z-
dc.date.available2014-09-09T18:23:23Z-
dc.date.issued2007-
dc.identifier.citationFREZARD, F. J. G. et al. A novel approach based on nanotechnology for investigating the chronic actions of short-lived peptides in specific sites of the brain. Regulatory Peptides, v. 138, p. 59-65, 2007. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0167011506002229>. Acesso em: 20 ago. 2014.pt_BR
dc.identifier.issn0167-0115-
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/3628-
dc.description.abstractThis review presents a novel experimental approach for investigating the chronic actions of short-lived peptides in specific sites of the brain. This method combines the advantages of three different techniques: liposome encapsulation, site-specific microinjection and telemetry. First, liposomes can be designed to remain located at the injection site for a long period of time, where they protect encapsulated peptide from rapid degradation and act as a sustained-release system. Secondly, microinjection allows the administration of peptides in specific sites of the brain with minimal side effects. Finally, using telemetry, it is possible to register physiological parameters and their circadian variations in undisturbed freemoving animals for several days. Angiotensin-(1–7) and angiotensin II were used as peptide models, in order to validate the proposed method. Following the unilateral microinjection of the liposome-encapsulated peptides into the rostral ventrolateral medulla (RVLM) of Wistar rats, longlasting cardiovascular actions were elicited, for several days. Importantly, new physiological actions of angiotensin-(1–7) at the RVLM were unmasked: modulation of the circadian rhythms of blood pressure and heart rate. It is felt that this method can be applied to a wide variety of shortlived bioactive peptides and should encounter numerous applications in the field of neurosciences.pt_BR
dc.language.isoen_USpt_BR
dc.subjectLiposomespt_BR
dc.subjectAngiotensinpt_BR
dc.subjectAngiotensinpt_BR
dc.titleA novel approach based on nanotechnology for investigating the chronic actions of short-lived peptides in specific sites of the brain.pt_BR
dc.typeArtigo publicado em periodicopt_BR
dc.rights.licenseO periódico Regulatory Peptides concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3456621031990.pt_BR
dc.description.abstractenhttps://doi.org/10.1016/j.regpep.2006.11.021-
Appears in Collections:DEFAR - Artigos publicados em periódicos

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