Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/jspui/handle/123456789/17873
Title: Copper(II)/diiminic complexes based on 2-hydroxybenzophenones : DNA-and BSA-binding studies and antitumor activity against HCT116 and HepG2 tumor cells.
Authors: Rodrigues, Júlia Helena Valadares
Carvalho, Alexandre Bizzotto de
Silva, Valdenizia Rodrigues
Santos, Luciano de Souza
Soares, Milena Botelho Pereira
Bezerra, Daniel Pereira
Oliveira, Katia Mara de
Correa, Rodrigo de Souza
Keywords: Copper - II
Diimines
2-Hydroxybenzophenones
Heteroleptic
Issue Date: 2023
Citation: RODRIGUES, J. H. V. et al. Copper(II)/diiminic complexes based on 2-hydroxybenzophenones: DNA-and BSA-binding studies and antitumor activity against HCT116 and HepG2 tumor cells. Polyhedron, v. 239, artigo 116431, 2023. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0277538723001535>. Acesso em: 01 ago. 2023.
Abstract: Here, we report four new heteroleptic Cu(II) complexes with the formula [Cu(bipy)(2H4MeBz)]NO3 (1), [Cu (phen)(2H4MeBz)]NO3 (2), [Cu(bipy)(2H4OcBz)]NO3 (3) and [Cu(phen)(2H4OcBz)]NO3 (4), where the ligands are 2-hydroxy-4-methoxybenzophenone (2H4MeBz), 2-hydroxy-4-(octyloxy)benzophenone (2H4OcBz), 2,2′ - bipiridine (bipy) and 1,10-phenantroline (phen). All compounds present two bidentate ligands, a monoanionic 2- hydroxybenzophenone, forming a six-membered chelate ring and the diiminic ring forming a five-membered chelate ring, as well as one nitrate as counterion located at the axial position, as suggested by the crystal structure of complex 2. Complex/DNA interaction studies were also performed using spectroscopic titration (Kb close to 104 M− 1 ), viscosity, Hoechst 33258 competition, and circular dichroism, revealing a moderate interaction between them. Additionally, complexes 1–4 moderately interact with BSA (Bovine Serum Albumin). The compounds were evaluated against HCT116 (human colon carcinoma) and HepG2 (human hepatocellular carcinoma) cancer cells and against MRC-5 (human lung fibroblast), a noncancer cells. The cytotoxic results suggest that complexes 2 and 4 are more cytotoxic than 1 and 3, showing that the presence of phen ligand may play an important role in increasing the biological effect of the compounds.
URI: http://www.repositorio.ufop.br/jspui/handle/123456789/17873
metadata.dc.identifier.uri2: https://www.sciencedirect.com/science/article/pii/S0277538723001535
metadata.dc.identifier.doi: https://doi.org/10.1016/j.poly.2023.116431
ISSN: 0277-5387
Appears in Collections:DEQUI - Artigos publicados em periódicos

Files in This Item:
File Description SizeFormat 
ARTIGO_CopperDiiminicComplexes.pdf
  Restricted Access
2,37 MBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.