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Title: Nitrosyl/Diphenylphosphine/Amino Acid–Ruthenium complexes as inhibitors of MDA-MB-231 breast cancer cells.
Authors: Barbosa, Marília Imaculada Frazão
Correa, Rodrigo de Souza
Macedo, Adriana Pereira Mundim Guedes
Graça, Alex Marchezini
Andrade, Francyelli Mello
Leite, Celisnolia Morais
Lacerda, Elisângela de Paula Silveira
Ellena, Javier Alcides
Silva, Henrique Vieira Reis
Doriguetto, Antônio Carlos
Batista, Alzir Azevedo
Keywords: Ruthenium
Amino acids
Nitric oxide
Breast cancer cells
Issue Date: 2023
Citation: BARBOSA, M. I. F. et al. Nitrosyl/Diphenylphosphine/Amino Acid–Ruthenium complexes as inhibitors of MDA-MB-231 breast cancer cells. Inorganics, v. 11, n. 7, artigo 270, 2023. Disponível em: <>. Acesso em: 01 ago. 2023.
Abstract: Herein, we report on the synthesis and characterization of ruthenium compounds with the general formula [RuCl(AA-H)(NO)(dppb]PF6 , where AA = glycine (1), L-alanine (2), L-phenylalanine (3) and L-valine (4), and dppb = 1,4-bis(diphenylphosphine)butane. The complexes were characterized using elemental analysis, UV/Vis and infrared spectroscopies, 1H, 13C, 31P NMR techniques, and cyclic voltammetry. Furthermore, the structures of the compounds (1) and (3) were determined using single-crystal X-ray diffraction. In vitro evaluation of the Ru(II)/nitrosyl/amino acid complexes revealed their cytotoxic activities against triple-negative MDA-MB-231 breast cancer cells, and against the non-tumor murine fibroblast cells. All the compounds decreased the percentage of viable cells, inducing cell death by apoptosis. Additionally, the Ru(II) complexes inhibited the migration of MDA-MB-231 cells at concentrations lower than 35 µM, after 48 h of exposure. Thus, these complexes may be promising agents for the treatment of triple-negative MDA-MB-231 breast cancer.
metadata.dc.rights.license: This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// 4.0/). Fonte: PDF do artigo.
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