Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/jspui/handle/123456789/17870
Title: New ruthenium complexes containing salicylic acid and derivatives induce triple-negative tumor cell death via the intrinsic apoptotic pathway.
Authors: Graminha, Angelica Ellen
Popolin, Cecília
Araujo Neto, João Honorato de
Correa, Rodrigo de Souza
Oliveira, Katia Mara de
Godoy, Luani Rezende
Colina Vegas, Legna Andreina
Ellena, Javier Alcides
Batista, Alzir Azevedo
Cominetti, Márcia Regina
Keywords: Ruthenium complexes
Salicylic acids
Cytotoxicity
Cell death
Issue Date: 2022
Citation: GRAMINHA, A. E. et al. New ruthenium complexes containing salicylic acid and derivatives induce triple-negative tumor cell death via the intrinsic apoptotic pathway. European Journal of Medicinal Chemistry, v. 243, artigo 114772, 2022. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0223523422006742>. Acesso em: 01 ago. 2023.
Abstract: In this work we present the synthesis and characterization of six new ruthenium compounds with general formulae [Ru(L)(dppb)(bipy)]PF6 and [Ru(L)(dppe)2]PF6 where L = salicylic acid (Sal), 4-aminosalicylic acid (AmSal) or 2,4-dihydroxybenzoic acid (DiSal), dppb = 1,4-bis(diphenylphosphino)butane, dppe = 1,2-bis (diphenylphosphino)ethane and bipy = 2,2′ -bipyridine. The complexes were characterized by elemental analysis, molar conductivity, cyclic voltammetry, NMR, UV–vis and IR spectroscopies, and two by X-ray crystallography. The 31P{1 H} NMR spectra of the complexes with the general formula [Ru(L)(dppe)2]PF6 showed that the phosphorus signals are solvent-dependent. Aprotic solvents, which form strong hydrogen bonds with the complexes, inhibit the free rotation of the salicylic acid-based, modifying the diphosphine cone angles, leading to distortion of the phosphorus signals in the NMR spectra. The cytotoxicity of the complexes was evaluated in MCF7, MDA-MB-231, SKBR3 human breast tumor cells, and MCF-10 non-tumor cell lines. The complexes with the structural formula [Ru(L)(dppe)2]PF6 were the most cytotoxic, and the complex [Ru(AmSal)(dppe)2]PF6 with L = 4-aminosalicylic acid ligand was the most selective for the MDA-MB-231 cell line. This complex interacts with the transferrin and induces apoptosis through the intrinsic pathway, as demonstrated by increased levels of proteins involved in apoptotic cell death.
URI: http://www.repositorio.ufop.br/jspui/handle/123456789/17870
metadata.dc.identifier.uri2: https://www.sciencedirect.com/science/article/pii/S0223523422006742
metadata.dc.identifier.doi: https://doi.org/10.1016/j.ejmech.2022.114772
ISSN: 0223-5234
Appears in Collections:DEQUI - Artigos publicados em periódicos

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