Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/jspui/handle/123456789/17690
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dc.contributor.authorRodriguez Herrera, Andrea Jazel-
dc.contributor.authorSouza, Ana Beatriz Farias de-
dc.contributor.authorCastro, Thalles de Freitas-
dc.contributor.authorMachado Júnior, Pedro Alves-
dc.contributor.authorMarcano Gomez, Elena Cecilia-
dc.contributor.authorMenezes, Tatiana Prata-
dc.contributor.authorCastro, Maria Laura da Cruz-
dc.contributor.authorSilva, André Talvani Pedrosa da-
dc.contributor.authorCosta, Daniela Caldeira-
dc.contributor.authorCangussú, Silvia Dantas-
dc.contributor.authorBezerra, Frank Silva-
dc.date.accessioned2023-10-30T19:50:59Z-
dc.date.available2023-10-30T19:50:59Z-
dc.date.issued2023pt_BR
dc.identifier.citationRODRIGUEZ HERRERA, A. J. et al. Long-term e-cigarette aerosol exposure causes pulmonary emphysema in adult female and male mice. Regulatory Toxicology and Pharmacology, v. 142, artigo 105412, ago. 2023. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0273230023000806>. Acesso em: 01 ago. 2023.pt_BR
dc.identifier.issn0273-2300-
dc.identifier.urihttp://www.repositorio.ufop.br/jspui/handle/123456789/17690-
dc.description.abstractThis study aimed to evaluate long-term exposure to conventional cigarette smoke (CC) and electronic cigarette (EC) aerosol in adult male and female C57BL/6 mice. Forty-eight C57BL/6 mice were used, male (n = 24) and female (n = 24), both were divided into three groups: control, CC and EC. The CC and EC groups were exposed to cigarette smoke or electronic cigarette aerosol, respectively, 3 times a day for 60 consecutive days. Afterwards, they were maintained for 60 days without exposure to cigarettes or electronic cigarette aerosol. Both cigarettes promoted an influx of inflammatory cells to the lung in males and females. All animals exposed to CC and EC showed an increase in lipid peroxidation and protein oxidation. There was an increase of IL-6 in males and females exposed to EC. The IL-13 levels were higher in the females exposed to EC and CC. Both sexes exposed to EC and CC presented tissue damage characterized by septal destruction and increased alveolar spaces compared to control. Our results demonstrated that exposure to CC and EC induced pulmonary emphysema in both sexes, and females seem to be more susceptible to EC.pt_BR
dc.language.isoen_USpt_BR
dc.rightsrestritopt_BR
dc.subjectCigarette smokept_BR
dc.subjectElectronic cigarettept_BR
dc.subjectC57BL/6 micept_BR
dc.titleLong-term e-cigarette aerosol exposure causes pulmonary emphysema in adult female and male mice.pt_BR
dc.typeArtigo publicado em periodicopt_BR
dc.identifier.uri2https://www.sciencedirect.com/science/article/pii/S0273230023000806pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.yrtph.2023.105412pt_BR
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