Please use this identifier to cite or link to this item:
Title: Caffeine prevents neurodegeneration and behavioral alterations in a mice model of agitated depression.
Authors: Machado, Daniele Guilhermano
Lara, Marcus Vinicius Soares
Dobler, Paula Bruna
Almeida, Roberto Farina de
Porciúncula, Lisiane de Oliveira
Keywords: Neurodegeneration
Adenosine receptors
Olfactory bulbectomy
Issue Date: 2020
Citation: MACHADO, D. G. et al. Caffeine prevents neurodegeneration and behavioral alterations in a mice model of agitated depression. Progress in Neuro-Psychopharmacology & Biological Psychiatry, v. 98, artigo 109776, mar. 2020. Disponível em: <>. Acesso em: 11 out. 2022.
Abstract: Longitudinal and some experimental studies have showed the potential of caffeine to counteract some depressive behaviors and synaptic dysfunctions. In this study, we investigated the potential of caffeine in preventing be- havioral outcomes, neurodegeneration and synaptic proteins alterations in a mice model of agitated depression by bilateral olfactory bulbectomy (OB). For this purpose, bulbectomized mice received caffeine (0.3 g/L and 1.0 g/L, drinking water), during the active cycle, for seven weeks (two before the surgery and throughout five weeks after OB). Caffeine prevented OBinduced hyperactivity and recognition memory impairment and rescue self care and motivational behavior. In the frontal cortex, bulbectomized mice presented increase in the ade- nosine A1 receptors (A1R) and GFAP, while adenosine A2A receptors (A2AR) increased in the hippocampus and striatum and SNAP-25 was decreased in frontal cortex and striatum. Caffeine increased A1R in the striatum of bulbectomized mice and in SHAM-water group caffeine increased A2AR in the striatum and decreased SNAP-25 in the frontal cortex. Astrogliosis observed in the polymorphic layer of the dentate gyrus of OB mice was pre- vented by caffeine as well as the neurodegeneration in the striatum and piriform cortex. Based on these beha- vioral and neurochemical evidences, caffeine confirms its efficacy in preventing neurodegeneration associated with memory impairment and may be considered as a promising therapeutic tool in the prophylaxis and/or treatment of depression.
ISSN: 1878-4216
Appears in Collections:DECBI - Artigos publicados em periódicos

Files in This Item:
File Description SizeFormat 
  Restricted Access
11,79 MBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.