Use este identificador para citar ou linkar para este item:
http://www.repositorio.ufop.br/jspui/handle/123456789/16550
Título: | Neurometabolic effects of sweetened solution intake during adolescence related to depressive-like phenotype in rats. |
Autor(es): | Arcego, Danusa Mar Olivo, Laura Bem Moraes, Rafael Oliveira Garcia, Emily dos Santos Silveira, Ana Caroline Krolow, Rachel Pereira, Natividade de Sa Couto Lampert, Carine Toniazzo, Ana Paula Nicola, Fabrício do Couto Sanches, Eduardo Farias Aristimunha, Dirceu Hoppe, Juliana Bender Klein, Caroline Peres Fontella, Fernanda Urruth Almeida, Roberto Farina de Gamaro, Giovana Duzzo Froes, Fernanda Carolina Telles da Silva Leite, Marina Concli Netto, Carlos Alexandre Zancan, Denise Maria Dalmaz, Carla |
Palavras-chave: | Artificial sweetener Aspartame Early life environment Mood disorders Dentate gyrus |
Data do documento: | 2020 |
Referência: | ARCEGO, D. M. et al. Neurometabolic effects of sweetened solution intake during adolescence related to depressive-like phenotype in rats. Nutrition, artigo 110770, p. 75-76, jul./ago. 2020. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0899900720300538?via%3Dihub>. Acesso em: 11 out. 2022. |
Resumo: | Objective: Exposure to artificial sweeteners, such as aspartame, during childhood and adolescence has been increasing in recent years. However, the safe use of aspartame has been questioned owing to its potentially harmful effects on the developing brain. The aim of this study was to test whether the chronic consumption of aspartame during adolescence leads to a depressive-like phenotype and to investigate the possible mecha- nisms underlying these behavioral changes. Methods: Adolescent male and female rats were given unlimited access to either water, solutions of aspar- tame, or sucrose in their home cages from postnatal day 21 to 55. Results: Forced swim test revealed that both chronic aspartame and sucrose intake induced depressive-like behaviord, which was more pronounced in males. Additionally, repeated aspartame intake was associated with increased cerebrospinal fluid (CSF) aspartate levels, decreased hippocampal neurogenesis, and reduced activation of the hippocampal leptin signaling pathways in males. In females, we observed a main effect of aspartame: reducing PI3K/AKT one of the brain-derived neurotrophic factor pathways; aspar- tame also increased CSF aspartate levels and decreased the immunocontent of the GluN2A subunit of the N-methyl-D-aspartic acid receptor. Conclusion: The findings revealed that repeated aspartame intake during adolescence is associated with a depressive-like phenotype and changes in brain plasticity. Interestingly, males appear to be more vulnerable to the adverse neurometabolic effects of aspartame than females, demonstrating a sexually dimorphic |
URI: | http://www.repositorio.ufop.br/jspui/handle/123456789/16550 |
Link para o artigo: | https://www.sciencedirect.com/science/article/pii/S0899900720300538?via%3Dihub |
DOI: | https://doi.org/10.1016/j.nut.2020.110770 |
ISSN: | 0899-9007 |
Aparece nas coleções: | DECBI - Artigos publicados em periódicos |
Arquivos associados a este item:
Arquivo | Descrição | Tamanho | Formato | |
---|---|---|---|---|
ARTIGO_NeurometabolicEffectsEweeted.pdf Restricted Access | 2,88 MB | Adobe PDF | Visualizar/Abrir |
Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.