Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/jspui/handle/123456789/16512
Title: L-arginine supplementation increases cardiac collagenogenesis in mice chronically infected with Berenice-78 Trypanosoma cruzi strain.
Authors: Narde, Maiara Bianchini
Domingues, Elisa Liz Belli Cassa
Gonçalves, Karolina Ribeiro
Vian, Mirelle Lomar
Zanini, Marcos Santos
Lima, Wanderson Geraldo de
Bahia, Maria Terezinha
Santos, Fabiane Matos dos
Keywords: Arginine
Nitric oxide
Chagas disease
Trypanosoma cruzi
Cardiomyopathy
Issue Date: 2021
Citation: NARDE, M. B. et al. L-arginine supplementation increases cardiac collagenogenesis in mice chronically infected with Berenice-78 Trypanosoma cruzi strain. Parasitology International, v. 83, artigo 102345, 2021. Disponível em: <https://www.sciencedirect.com/science/article/pii/S1383576921000647>. Acesso em: 11 out. 2022.
Abstract: Chagas disease, caused by Trypanosoma cruzi, is a major neglected tropical disease that occurs mainly as chronic infection and systemic infection. Currently, there is no suitable and effective drug to treat this parasitic disease. Administration of nutrients with immunomodulatory properties, such as arginine and nitric oxide radicals, may be helpful as antiparasitic therapy. In this study, we evaluated the effects of arginine supplementation during the acute phase of infection under the development of chronic Chagas’ heart disease in Swiss mice inoculated with the Berenice-78 strain of T. cruzi. The effectiveness of arginine was determined by daily detection of the parasite in the blood and long-term serum levels of nitric oxide and tumor necrosis factor-alpha, in addition to evaluation of heart tissue damage. Arginine could flatten parasitemia and prevent elevation of tumor necrosis factor-alpha in T. cruzi-infected mice. Regarding chronic inflammatory myocardial derangements, similar findings were verified among T. cruzi-infected groups. Arginine promoted collagenogenesis in the heart muscle tissue of T. cruzi-infected arginine-supplemented group. These data show the paradoxical benefits of arginine in improving the outcome of Chagas chronic cardiomyopathy.
URI: http://www.repositorio.ufop.br/jspui/handle/123456789/16512
metadata.dc.identifier.uri2: https://www.sciencedirect.com/science/article/pii/S1383576921000647
metadata.dc.identifier.doi: https://doi.org/10.1016/j.parint.2021.102345
ISSN: 1383-5769
Appears in Collections:DECBI - Artigos publicados em periódicos

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