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Title: Identification of a bioactive compound isolated from Brazilian propolis type 6.
Authors: Castro, Myrella Lessio
Nascimento, Andréa Mendes do
Ikegaki, Masaharu
Costa Neto, Cláudio Miguel da
Alencar, Severino Matias de
Rosalen, Pedro Luiz
Keywords: Prenylated benzophenone hyperibone A
Biological activity
Brazilian propolis
Issue Date: 2009
Citation: CASTRO, M. L. et al. Identification of a bioactive compound isolated from Brazilian propolis type 6. Bioorganic & Medicinal Chemistry, v. 17, n. 14, p. 5332-5335, jul. 2009. Disponível em: <>. Acesso em: 09 out. 2012.
Abstract: A prenylated benzophenone, hyperibone A, was isolated from the hexane fraction of Brazilianpropolistype6. Its structure was determined by spectral analysis including 2D NMR. This compound exhibited cytotoxic activity against HeLa tumor cells (IC50 = 0.1756 μM), strong antimicrobial activity (MIC range—0.73–6.6 μg/mL; MBC range—2.92–106 μg/mL) against Streptococcus mutans, Streptococcus sobrinus, Streptococcus oralis, Staphylococcus aureus, and Actinomyces naeslundii, and the results of its cytotoxic and antimicrobial activities were considered good.
ISSN: 09680896
metadata.dc.rights.license: O periódico Bioorganic & Medicinal Chemistry concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3310910618604.
Appears in Collections:DEQUI - Artigos publicados em periódicos

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