Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/jspui/handle/123456789/15747
Title: Stability and degradation kinetics of an ethanolic extract and tincture of aerial parts from lychnophora passerina (Brazilian arnica).
Authors: Ugoline, Bruno César de Albuquerque
Souza, Jacqueline de
Caldeira, Tamires Guedes
Guimarães, Dênia Antunes Saúde
Keywords: Herbal medicinal product
Stability studies
Issue Date: 2021
Citation: UGOLINE, B. C. de A. et al. Stability and degradation kinetics of an ethanolic extract and tincture of aerial parts from lychnophora passerina (Brazilian arnica). Revista Brasileira de Farmacognosia, v. 31, p. 453-462, 2021. Disponível em: <https://link.springer.com/article/10.1007/s43450-021-00178-x>. Acesso em: 11 out. 2022.
Abstract: Previous studies have demonstrated the anti-infammatory and antihyperuricemic activities of dried ethanolic extract of the aerial parts of Lychnophora passerina (Mart ex DC.) Gardner, Asteraceae, and then the potential to become a pharmaceutical product. However, many of the constituents present in these medicines can be degraded, raising serious concerns about the stability of products. Considering the impact on the quality of herbal medicines, this study evalu- ated the stability of a dried ethanolic extract and tincture of the aerial parts of L. passerina. For the accelerated stability study, the dried ethanolic extract and tincture were stored at 40±2 °C for 6 months. For the long-term stability study, the dried ethanolic extract was stored at 30±2 °C for 12 months. The organoleptic properties and goyazensolide content were analyzed. The pH, relative density, and dry residue were evaluated for the tincture. In addition, forced degradation and stability studies at room temperature (25±2 °C) were carried out. In glass bottles that were hermetically sealed and protected from light, the dried ethanolic extract remained stable for 3 months when stored at 30±2 °C and for 12 months at 25±2 °C. The tinctures remained stable for 6 months when stored at 25±2 °C. In addition, the dried ethanolic extract and tincture showed zero-order degradation kinetics. The dried ethanolic extract and tincture of L. passerina had greater stability when compared to preparations of other species of Lychnophora. Thus, this species could be directed for phar- maceutical preparations aimed at use by the population.
URI: http://www.repositorio.ufop.br/jspui/handle/123456789/15747
metadata.dc.identifier.uri2: https://link.springer.com/article/10.1007/s43450-021-00178-x
metadata.dc.identifier.doi: https://doi.org/10.1007/s43450-021-00178-x
ISSN: 1981-528X
Appears in Collections:DEFAR - Artigos publicados em periódicos

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