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dc.contributor.authorFerreira, Gabriel Monteze-
dc.contributor.authorSilva, Breno de Mello-
dc.contributor.authorSouza, Gustavo Henrique Bianco de-
dc.contributor.authorOliveira, Alaíde Braga de-
dc.contributor.authorBrandão, Geraldo Célio-
dc.identifier.citationFERREIRA, G. M. et al. Anti-zika activity of Ouratea semiserrata and dereplication of its constituents. Revista Brasileira de Farmacognosia, v. 31, p. 121-125, 2021. Disponível em: <>. Acesso em: 11 out. 2022.pt_BR
dc.description.abstractZika virus is an arbovirus that has vector mosquitoes of the genus Aedes. In adult humans, the infection may be asymptomatic or present mild symptoms such as itching and low fever. However, the infection is associated with other severe problems, which encouraged investigations for an effective treatment against this virus. This work evaluated the potential anti-Zika virus effect of the ethanolic extract of Ouratea semiserrata (Mart. & Nees) Engl., Ochnaceae, a medicinal plant popularly used in Brazil for the treatment of viral infections. The extract of the stems was prepared by cold percolation using ethanol as solvent and its content dereplicated by ultra-high-performance liquid chromatography-diode array detector-tandem mass spectrometry. Phenolic com- pounds including rutin, catechin, and epicatechin were identified as the major constituents. The antiviral activity was tested in vitro against Zika virus by the MTT colorimetric method. The ethanol extract inhibited the viral replication cycle with an EC50 of 37.5 μg/ml, and at the concentration of 100 μg/ml, a 100% inhibition of the viral cytopathic effect was obtained. Rutin and epicatechin inhibited viral cytopathic effect in Vero cells with EC50 > 50.00 μg/ml.pt_BR
dc.subjectAnti-arboviral activitypt_BR
dc.subjectNatural productspt_BR
dc.titleAnti-zika activity of Ouratea semiserrata and dereplication of its constituents.pt_BR
dc.typeArtigo publicado em periodicopt_BR
Appears in Collections:DEFAR - Artigos publicados em periódicos

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