Use este identificador para citar ou linkar para este item:
http://www.repositorio.ufop.br/jspui/handle/123456789/15727
Título: | Benznidazole, itraconazole, and their combination for the treatment of chronic experimental Chagas disease in dogs. |
Autor(es): | Cunha, Eleonora Lima Alves Torchelsen, Fernanda Karoline Vieira da Silva Fonseca, Kátia da Silva Sousa, Lucas Resende Dutra Vieira, Paula Melo de Abreu Carneiro, Cláudia Martins Pinto, Kelerson Mauro de Castro Torres, Rosália Morais Lana, Marta de |
Palavras-chave: | Chemotherapy Drug combinations Dog model |
Data do documento: | 2022 |
Referência: | CUNHA, E. L. A. et al. Benznidazole, itraconazole, and their combination for the treatment of chronic experimental Chagas disease in dogs. Experimental Parasitology, v. 238, 2022. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0014489422000601?via%3Dihub>. Acesso em: 11 out. 2022. |
Resumo: | Treatment for Chagas disease has limited efficacy in the chronic phase. We evaluated benznidazole (BZ) and itraconazole (ITZ) individually and in association in dogs 16 months after infection with a BZ-resistant Trypa- nosoma cruzi strain. Four study groups (20 animals) were evaluated and treated for 60 days with BZ, ITZ, or BZ + ITZ, and maintained in parallel to control group infected and not treated (INT). All dogs were evaluated in the first, sixth, 12th, 18th and 24th months of study. Polymerase chain reaction (PCR) was negative in 2 of 3 animals in the BZ + ITZ group, 2 of 5 in the BZ group, and 4 of 5 in the ITZ group. Hemoculture performed in the 24th month was negative in all groups. Enzyme-linked immunoassay remained reactive in all treated animals. Echocardiography differentiated treated animals from control animals. Quantitative PCR analysis of cardiac tissue was negative in the BZ + ITZ and BZ groups, positive in 2 of 5 dogs in the ITZ group and in 2 of 3 dogs in the control group, but negative in colon tissue in all groups. Inflammation was significantly reduced in the right atrium and left ventricle of dogs treated with BZ + ITZ and BZ compared with those receiving ITZ alone. Fibrosis was absent in most dogs treated with BZ + ITZ, mild in those treated with BZ or ITZ alone, and intense in the control group. Parasitological and histopathological evaluations showed that BZ + ITZ treatment improved or stabilized the clinical condition of the dogs. |
URI: | http://www.repositorio.ufop.br/jspui/handle/123456789/15727 |
Link para o artigo: | https://www.sciencedirect.com/science/article/pii/S0014489422000601?via%3Dihub |
DOI: | https://doi.org/10.1016/j.exppara.2022.108266 |
ISSN: | 0014-4894 |
Aparece nas coleções: | DEEFD - Artigos publicados em periódicos |
Arquivos associados a este item:
Arquivo | Descrição | Tamanho | Formato | |
---|---|---|---|---|
ARTIGO_BenznidazoleitraconazoleCombination.pdf Restricted Access | 2,68 MB | Adobe PDF | Visualizar/Abrir |
Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.