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Title: In vitro photoprotective evaluation and development of novel nanoemulsion with chromone derivative.
Authors: Antunes, Amanda dos Santos
Gouveia, Ana Paula Araújo
Diogo, Gabriela Maciel
Taylor, Jason Guy
Sousa, Lucas Resende Dutra
Amparo, Tatiane Roquete
Perasoli, Fernanda Barçante
Santos, Orlando David Henrique dos
Cazati, Thiago
Vieira, Paula Melo de Abreu
Penido, Ricardo Gonçalves
Santos, Viviane Martins Rebello dos
Keywords: Mansur
Organic UV filters
Issue Date: 2021
Citation: ANTUNES, A. dos S. et al. In vitro photoprotective evaluation and development of novel nanoemulsion with chromone derivative. Journal of the Brazilian Chemical Society, v. 32, n. 9, p. 1813-1821, 2021. Disponível em: <>. Acesso em: 10 jun. 2021.
Abstract: Chromone derivatives exhibiting high absorbance values in the UVA/UVB region were synthesized, and their photoprotective properties were evaluated. Chromones were prepared according to known literature procedures and characterized by high resolution mass spectrometry, infrared (IR) and nuclear magnetic resonance (NMR) spectroscopy. The in vitro solar protection factor (SPF) was determined by the Mansur method and cytotoxicity was evaluated using the sulforhodamine B assay. Two of the chromones synthesized demonstrated suitable SPF values and displayed no cytotoxic effect towards MRC-5 human fibroblasts at the tested concentrations, indicating great potential for future in vivo assays and clinical trials. Finally, the lead compound was incorporated into a nanoemulsion. Nanoemulsions showed high droplet size homogeneity and excellent stability. Chromones bearing methoxy substituents were found to be the most promising compounds with ideal photoprotective properties desirable for utilization and incorporation in sunscreen formulations.
ISSN: 1678-4790
metadata.dc.rights.license: This is an open-access article distributed under the terms of the Creative Commons Attribution License. Fonte: o PDF do artigo.
Appears in Collections:DEQUI - Artigos publicados em periódicos

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