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Title: Assessment of the biological potential of diaryltriazene-derived triazene compounds.
Authors: Figueirêdo, Patricia de Maria Silva
Sampaio Filho, José Costa
Sodré, Alzirene de Jesus Sales
Castro Júnior, José Ribamar de
Gonçalves, Ingrid Santos
Blasques, Rodrigo Vieira
Correa, Rodrigo de Souza
Lima, Benedicto Augusto Vieira
Marques, Larissa dos Anjos
Coutinho, Denise Fernandes
Santos, Ana Paula Silva de Azevedo dos
Luz, Tássio Rômulo Silva Araújo
Miranda, Rita de Cassia Mendonça de
Santos, Julliana Ribeiro Alves dos
Doriguetto, Antônio Carlos
Pividori, María Isabel
Hörner, Manfredo
Villis, Paulo Cesar Mendes
Issue Date: 2021
Citation: FIGUEIRÊDO, P. de M. S. et al. Assessment of the biological potential of diaryltriazene-derived triazene compounds. Scientific Reports, v. 11, artigo 2541, 2021. Disponível em: <>. Acesso em: 10 jun. 2021.
Abstract: In the present study, novel, 1,3-diaryltriazene-derived triazene compounds were synthesized and tested. Triazenes are versatile and belong to a group of alkylating agents with interesting physicochemical properties and proven biological activities. This study describes the synthesis, molecular and crystalline structure, biological activity evaluation, and antifungal and antimicrobial potentials of 1,3-bis(X-methoxy-Y-nitrophenyl)triazenes [X= 2 and 5; Y= 4 and 5]. The antimicrobial and antifungal activities of the compounds were tested by evaluating the sensitivity of bacteria (American Type Culture Collection, ATCC) and clinical isolates to their solutions using standardized microbiological assays, cytotoxicity evaluation, and ecotoxicity tests. The antimicrobial potentials of triazenes were determined according to their minimum inhibitory concentrations (MICs); these compounds were active against gram-positive and gram-negative bacteria, with low MIC values. The most surprising result was obtained for T3 having the efective MIC of 9.937 µg/mL and antifungal activity against Candida albicans ATCC 90028, C. parapsilosis ATCC 22019, and C. tropicallis IC. To the best of our knowledge, this study is the frst to report promising activities of triazene compounds against yeast and flamentous fungi. The results showed the potential utility of triazenes as agents afecting selected resistant bacterial and fungal strains.
metadata.dc.rights.license: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. Fonte: o PDF do artigo.
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