Please use this identifier to cite or link to this item: http://www.repositorio.ufop.br/jspui/handle/123456789/14249
Title: New heteroleptic RuII/diphosphine complexes with cytotoxicity against human breast and murine ascitic sarcoma 180 tumor cells.
Authors: Lima, Benedicto Augusto Vieira
Correa, Rodrigo de Souza
Graminha, Angelica Ellen
Varela Júnior, Jaldyr de Jesus Gomes
Silva, Albérico Borges Ferreira da
Ellena, Javier Alcides
Silva, Thales E. M.
Batista, Alzir Azevedo
Keywords: Picolinate
Biphosphines
Issue Date: 2020
Citation: LIMA, B. A. V. et al. New heteroleptic RuII/diphosphine complexes with cytotoxicity against human breast and murine ascitic sarcoma 180 tumor cells. Journal of the Brazilian Chemical Society, v. 31, n. 7, p. 1352-1361, 2020. Disponível em: <http://static.sites.sbq.org.br/jbcs.sbq.org.br/pdf/2019-0506AR.pdf>. Acesso em: 10 jun. 2021.
Abstract: The preparation, characterization, theoretical calculations and biological application of four RuII complexes with 2-picolinate (pic), 2,2’-bipyridine (bipy) and P-P as ligands [P-P = 1,1-bis(diphenylphosphino)methane (dppm-1), 1,2-bis(diphenylphosphino)ethane (dppe-2), 1,3-bis(diphenylphosphino)propane (dppp-3) or 1,1’-bis(diphenylphosphino)ferrocene (dppf-4)], is here presented. The complexes 1-4, with general formula [Ru(pic)(P-P)(bipy)]PF6, were characterized by elemental analysis and by infrared (IR), UV-Vis, nuclear magnetic resonance (NMR 1 H and 13P{1 H}) spectroscopies, cyclic voltammetry and X-ray crystallography technique. Additionally, preliminary in vitro tests against human breast (MDA-MB-231) and murine ascitic sarcoma 180 (S180) tumor cell lines were carried out, and compared with cisplatin, a reference drug. The drug concentration at which 50% of the cells are viable relative to the control (IC50) values found for complexes 1, 2, 3 and 4 against MDA-MB-231 tumor cells were around 14.6, 7.6, 3.3 and 0.4 μM, respectively, while against S180 tumor cells these complexes showed IC50 values of 71.9, 31.3, 11.2 and 3.5 μM, respectively. Therefore, the complexes were more active against MDA-MB-231 than S180.
URI: http://www.repositorio.ufop.br/jspui/handle/123456789/14249
metadata.dc.identifier.doi: http://dx.doi.org/10.21577/0103-5053.20200020
ISSN: 1678-4790
metadata.dc.rights.license: This is an open-access article distributed under the terms of the Creative Commons Attribution License. Fonte: o PDF do artigo.
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