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Title: "Half-sandwich"/RuII anticancer complexes containing triphenylphosphine and p-substituted benzoic acids.
Authors: Araujo Neto, João Honorato de
Oliveira, Katia Mara de
Leite, Celisnolia Morais
Colina Vegas, Legna Andreina
Nóbrega, Joaquim de Araújo
Castellano, Eduardo Ernesto
Ellena, Javier Alcides
Correa, Rodrigo de Souza
Batista, Alzir Azevedo
Keywords: Piano-stool RuII complexes
Benzoic acid analogs
Cellular uptake
Issue Date: 2020
Citation: ARAÚJO NETO, J. H. de et al. "Half-sandwich"/RuII anticancer complexes containing triphenylphosphine and p-substituted benzoic acids. Journal of the Brazilian Chemical Society, v. 31, p. 2237-2249, 2020. Disponível em: <>. Acesso em: 10 jun. 2021.
Abstract: Mononuclear and binuclear RuII/arene/triphenylphosphine complexes with p-substituted benzoic acid derivatives were prepared and characterized. These monocationic complexes of type [Ru(η6 -p-cymene)(PPh3)L] (L = benzoic acid (1), p-hydroxybenzoic acid (2), p-nitrobenzoic acid (3) and terephthalic acid (4)) were characterized using various techniques, such as nuclear magnetic resonance (NMR) and matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF) mass spectrometry, and the crystal structure of 1, 3 and 4 were determined by X-ray diffraction analysis. The cytotoxicity of the complexes was evaluated, in vitro, against tumorigenic [MDA-MB-231, MCF-7 (breast), A549 (lung) and DU-145 (prostate)] and non-tumorigenic [MCF-10A (breast), MRC-5 (lung) and PNT-2 (prostate)] cells. The binuclear complex (4) was inactive due to its low solubility. Complexes 1, 2 and 3 showed similar cytotoxicity, however, complex 1 presented better selectivity index against MDA-MB-231 than compounds 2 and 3. Cellular ruthenium absorption was explored by inductively coupled plasma mass spectrometry (ICP-MS) analyzing the whole cells and the culture medium. Complementary studies showed that complex 1 inhibited colony formation, induced morphology changes in cells and promoted cell cycle arrest in the Sub-G1 phase for the MDA-MB-231 cells.
ISSN: 1678-4790
metadata.dc.rights.license: This is an open-access article distributed under the terms of the Creative Commons Attribution License. Fonte: o PDF do artigo.
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