Please use this identifier to cite or link to this item:
Title: High levels of chemerin associated with variants in the NOS3 and APOB genes in rural populations of Ouro Preto, Minas Gerais, Brazil.
Authors: Batista, Aline Priscila
Barbosa, Keila Furbino
Masioli, Cássio Zumerle
Queiroz, Erica Maria de
Marinho, Carolina Coimbra
Cândido, Ana Paula Carlos
Coelho, George Luiz Lins Machado
Issue Date: 2020
Citation: BATISTA, A. P. et al. High levels of chemerin associated with variants in the NOS3 and APOB genes in rural populations of Ouro Preto, Minas Gerais, Brazil. Brazilian Journal of Medical and Biological Research, v. 53, n. 6, 2020. Disponível em: <>. Acesso em: 10 jun. 2021.
Abstract: Chemerin is an adipokine that has been associated with components of metabolic syndrome. It has been described to affect adipocyte metabolism and inflammatory responses in adipose tissue, as well as the systemic metabolism of lipids and glucose. Few epidemiological studies have evaluated classical and genetics cardiovascular risk factors (CVRFs) in the mixed adult rural population in Brazil. Therefore, the present study explored possible associations between CVRFs and chemerin. This cross sectional study included 508 adults from the rural localities of Lavras Novas, Chapada, and Santo Antônio do Salto in Ouro Preto, Minas Gerais, Southeast Brazil. Demographic, behavioral, clinical, biochemical, anthropometric variables, and 12 single nucleotide polymorphisms (SNPs) linked with metabolic syndrome phenotypes were evaluated for associations with chemerin level. There was a significant association of high triglyceride levels [odds ratio (OR)=1.91, 95%CI: 1.23–2.98], insulin resistance (OR=1.82, 95%CI: 1.03–3.22), age (OR=1.64, 95%CI: 1.08–2.49), and sex (OR=1.99, 95%CI: 1.35–2.95) with high levels of chemerin. High chemerin levels were significantly associated with the genetic polymorphisms rs693 in the APOB gene (OR=1.50, 95%CI: 1.03–2.19) and rs1799983 in the NOS3 gene (OR=1.46, 95%CI: 1.01–2.12) for the AA and GT+TT genotypes, respectively. In the concomitant presence of genotypes AA of rs693 and GT+TT of rs1799983, the chance of presenting high levels of chemerin showed a 2.21-fold increase (95%CI: 1.25–3.88) compared to the reference genotype. The development of classical CVRFs in this population may be influenced by chemerin and by two risk genotypes characteristic of variants in well-studied genes for hypertension and dyslipidemia.
ISSN: 1414-431X
metadata.dc.rights.license: This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Fonte: o PDF do artigo.
Appears in Collections:DEMSC - Artigos publicados em periódicos

Files in This Item:
File Description SizeFormat 
ARTIGO_HighLevelsChemerin.pdf269,81 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.