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Title: Lipoprotein(a) levels in children and adolescents : Ouro Preto study.
Authors: Cândido, Ana Paula Carlos
Mendes, Alekson Mendonça
Candido, Debora Rosa Carlos
Nicolato, Roney Luiz de Carvalho
Coelho, George Luiz Lins Machado
Keywords: Cholesterol
Body Mass Index
Bod Fat
Issue Date: 2020
Citation: CÂNDIDO, A. P. C. et al. Lipoprotein(a) levels in children and adolescents: Ouro Preto study. International Journal of Cardiovascular Sciences, v. 34, p. 10-18, 2020. Disponível em: <>. Acesso em: 10 jun. 2021.
Abstract: Background: Lipoprotein (a) is a cardiovascular risk factor in adult. Studies have shown the presence of this emergent risk factor in school children, which may contribute to the development of atherosclerosis in adulthood. Objective: To evaluate the association between lipoprotein (a) and cardiovascular risk factors in school children. Methods: Lipoprotein (a) levels were measured in 320 school children (6-14 years) selected from a population survey carried out in Ouro Preto (southeast of Brazil). Demographic (sex and age), biochemical (total cholesterol, high density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, triglycerides, and glucose), anthropometric (body mass index, waist circumference, body fat percentage), clinical (arterial blood pressure, pubertal stage and birth weight) and economic (family income) parameters, as well as family history (obese and/or hypertensive parents) were analyzed. Non-parametric analysis was used to evaluate lipoprotein (a) levels in each subgroup. Variables with p≤0.20 in the univariate analysis were included in binary regression logistic model. Differences with p < 0.05 were considered significant. Results: Lipoprotein (a) levels were associated with total cholesterol (p=0.04), body fat (p=0.009), and mother´s systolic (p=0.02) and diastolic blood pressure (p=0.04). In a logistic regression analysis, children with high lipoprotein (a) levels and body fat, and children born from hypertensive mothers were, respectively, at 3.2(p=0.01) and 1.4 (p=0.03) times higher risk than other children. In clustering these factors, elevated lipoprotein (a) was 2.6 times more likely to be seen in school children with high body fat and born hypertensive mothers. Conclusions: Lipoprotein (a) was correlated with cardiovascular risk factors in children and adolescents. Persistence of these risk factors in childhood suggests a contribution of elevated lipoprotein (a) to future cardiovascular disease.
ISSN: 2359-5647
metadata.dc.rights.license: This is an open-access article distributed under the terms of the Creative Commons Attribution License. Fonte: o PDF do artigo.
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