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http://www.repositorio.ufop.br/jspui/handle/123456789/14116
Título: | Synthesis of novel papulacandin D analogs and evaluation of their antifungal potential. |
Autor(es): | Bretas, Ana Carolina Oliveira Souza, Thiago Belarmino de Borelli, Beatriz Johan, Suzana Alves, Ricardo José |
Palavras-chave: | β-(1,3)-D-glucan synthase Molecular simplification |
Data do documento: | 2020 |
Referência: | BRETAS, A. C. O. et al. Synthesis of novel papulacandin D analogs and evaluation of their antifungal potential. Brazilian Journal of Pharmaceutical Sciences, v. 56, 2020. Disponível em: <https://www.scielo.br/j/bjps/a/9WyRKPhrqfMknLVVr9ZFnhj/>. Acesso em: 10 jun. 2021. |
Resumo: | Systemic fungal infections are a growing problem in contemporary medicine and few drugs are licensed for therapy of invasive fungal infections. Differences between fungi and humans, like the presence of a cell wall in fungal cells, can be explored for designing new drugs. (1,3)-β-D-glucan synthase, an enzyme that catalyzes the synthesis of (1,3)-β-D-glucan, a structural and essential component of the fungal cell wall, is absent in mammals and this makes it an excellent target for the development of new antifungal agents. Papulacandins are a family of natural antifungal agents targeting (1,3)-β-D-glucan synthase. In this study we describe the synthesis and biological evaluation of two new Papulacandin analogs as potential (1,3)-β-D-glucan synthase inhibitors. |
URI: | http://www.repositorio.ufop.br/jspui/handle/123456789/14116 |
DOI: | https://doi.org/10.1590/s2175-97902019000417652 |
ISSN: | 2175-9790 |
Licença: | This is an open-access article distributed under the terms of the Creative Commons Attribution License. Fonte: o PDF do artigo. |
Aparece nas coleções: | DEFAR - Artigos publicados em periódicos |
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ARTIGO_SynthesisNovelPapulacandi.pdf | 784,08 kB | Adobe PDF | Visualizar/Abrir |
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