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Título: | Synthesis of eugenol-derived glucosides and evaluation of their ability in inhibiting the angiotensin converting enzyme. |
Autor(es): | Alvarenga, Dalila Junqueira Matias, Laira Maria Faria Cordeiro, Cleydson Finotti Souza, Thiago Belarmino de Lavorato, Stefânia Neiva Pereira, Marília Gabriella Alves Goulart Dias, Danielle Ferreira Carvalho, Diogo Teixeira |
Data do documento: | 2020 |
Referência: | ALVARENGA, D. J. et al. Synthesis of eugenol-derived glucosides and evaluation of their ability in inhibiting the angiotensin converting enzyme. Natural Product Research, 2020. Disponível em: <https://www.tandfonline.com/doi/abs/10.1080/14786419.2020.1827399?journalCode=gnpl20>. Acesso em: 10 jun. 2021. |
Resumo: | We report here a series of glucosides which are active as inhibi tors of the angiotensin converting enzyme (ACE). They are struc turally related to the natural compound eugenol and exhibited significant inhibition values. Their syntheses were expeditious and we could obtain informative docking plots of them complexed to this enzyme. A glucoside derived from eugenol, carrying a carbox ylic group in the aglycone, was the most active of them (with an IC50 of 0.4 mM) and showed good binding energies in docking studies with ACE. Moreover, computational prediction of toxicity risks, physicochemical properties and drug score show that the glucoside derivative of eugenol is a suitable compound for opti misation studies aimed at finding new drug candidates. |
URI: | http://www.repositorio.ufop.br/jspui/handle/123456789/14115 |
Link para o artigo: | https://www.tandfonline.com/doi/abs/10.1080/14786419.2020.1827399?journalCode=gnpl20 |
DOI: | https://doi.org/10.1080/14786419.2020.1827399 |
ISSN: | 1478-6427 |
Aparece nas coleções: | DEFAR - Artigos publicados em periódicos |
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Arquivo | Descrição | Tamanho | Formato | |
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ARTIGO_SynthesisEugenolDerived.pdf Restricted Access | 1,33 MB | Adobe PDF | Visualizar/Abrir |
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