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Title: Trypanosoma cruzi : impact of dual-clone infections on parasite biological properties in BALB/c mice.
Authors: Martins, Helen Rodrigues
Toledo, Max Jean de Ornelas
Veloso, Vanja Maria
Carneiro, Cláudia Martins
Coelho, George Luiz Lins Machado
Tafuri, Washington Luiz
Bahia, Maria Terezinha
Valadares, Helder Magno Silva
Macedo, Andréa Mara
Lana, Marta de
Issue Date: 2006
Citation: MARTINS, H. R. et al. Trypanosoma cruzi : impact of dual-clone infections on parasite biological properties in BALB/c mice. Experimental Parasitology, v. 112, n.4, p. 237-246, abr. 2006. Disponível em: <>. Acesso em: 20 set. 2012.
Abstract: Herein, we have analyzed major biological properties following dual-clone Trypanosoma cruzi infections in BALB/c mice. Eight T. cruzi clonal stocks, two of each principal genotype, including genotype 19 and 20 (T. cruzi I), hybrid genotype 39 (T. cruzi) and 32 (T. cruzi II) were combined into 24 diVerent dual-clone infections. Special attention was given to characterize biological parameters assayed including: prepatent period, patent period, maximum of parasitemia, day of maximum parasitemia, area under the parasitemia curve, infectivity, mortality, and hemoculture positivity. Our Wndings clearly demonstrated that features resultant of dual-clone infections of T. cruzi clonal stocks did not display either the characteristics of the corresponding monoclonal infections or the theoretical mixture based on the respective monoclonal infections. SigniWcant changes in the expected values were observed in 4.2–79.2% of the mixtures considering the eight biological parameters studied. A lower frequency of signiWcant diVerences was found for mixtures composed by phylogenetically distant clonal stocks. Altogether, our data support our hypothesis that mixed T. cruzi infections have a great impact on the biological properties of the parasite in the host and re-emphasizes the importance of considering the possible occurrence of natural mixed infections in humans and their consequences on the biological aspects of ongoing Chagas’ disease.
ISSN: 00144894
metadata.dc.rights.license: O periódico Experimental Parasitology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3281990662321.
Appears in Collections:DEACL - Artigos publicados em periódicos

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