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Title: Associating chitosan and microemulsion as a topical vehicle for the administration of herbal medicines.
Authors: Oliveira, Denise A. J.
Amaral, Juliano G.
Garcia, Laryana Borges
Santos, Milena Soares dos
Silva, Lorena A. O.
Almeida, Maiara Prates de
Gomes, Angélica Ferraz
Barros, Danielle R. P.
Lopes, Norberto Peporine
Pereira, Gislaine Ribeiro
Santos, Orlando David Henrique dos
Ruela, André Luís Morais
Keywords: Liquid crystal
Molecular networking
Issue Date: 2021
Citation: OLIVEIRA, D. A. J. et al. Associating chitosan and microemulsion as a topical vehicle for the administration of herbal medicines. Carbohydrate Polymers, v. 255, p. 117482, 2021. Disponível em: <>. Acesso em: 10 jun. 2021.
Abstract: A viscous solution of low molecular weight chitosan (CH) at 5% w/v (10.2 kDa, 75 % deacetylated, 1451 cP at 25 ◦C) was associated with a microemulsion (ME) that undergoes a phase transition after water absorption in situ (≈28 % w/w), forming a more viscous liquid crystal, which was potentially evaluated as a topical vehicle. The ME was selected from a phase diagram, selecting a composition based on Tween® 80 (52 %), myristate isopropyl (28 %), and the aqueous phase (water and polyethylene glycol 400, 60:40 w/w) (20 %), which was after replaced by CH and herbal medicines (HM). HM are alternatives to treat candidiasis, and Stryphnodendron adstringens shell extract, characterized by molecular networking, and Melaleuca alternifolia Chell essential oil (46 % of terpinen-4- ol), showed in vitro activity against Candida albicans. Associating CH in ME improved the mechanical properties of the topical formulation, as adhesiveness, which is an advantageous feature for the topical treatment of vul vovaginal candidiasis.
ISSN: 0144-8617
Appears in Collections:DEFAR - Artigos publicados em periódicos

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