Use este identificador para citar ou linkar para este item:
http://www.repositorio.ufop.br/jspui/handle/123456789/14107
Título: | Associating chitosan and microemulsion as a topical vehicle for the administration of herbal medicines. |
Autor(es): | Oliveira, Denise Aline de Jesus Amaral, Juliano Geraldo Garcia, Laryana Borges Santos, Milena Soares dos Silva, Lorena A. O. Almeida, Maiara Prates de Gomes, Angélica Ferraz Barros, Danielle Rocha Pinho Lopes, Norberto Peporine Pereira, Gislaine Ribeiro Santos, Orlando David Henrique dos Ruela, André Luís Morais |
Palavras-chave: | Liquid crystal Adhesiveness Rheology Molecular networking |
Data do documento: | 2021 |
Referência: | OLIVEIRA, D. A. J. et al. Associating chitosan and microemulsion as a topical vehicle for the administration of herbal medicines. Carbohydrate Polymers, v. 255, p. 117482, 2021. Disponível em: <https://www.sciencedirect.com/science/article/abs/pii/S0144861720316556>. Acesso em: 10 jun. 2021. |
Resumo: | A viscous solution of low molecular weight chitosan (CH) at 5% w/v (10.2 kDa, 75 % deacetylated, 1451 cP at 25 ◦C) was associated with a microemulsion (ME) that undergoes a phase transition after water absorption in situ (≈28 % w/w), forming a more viscous liquid crystal, which was potentially evaluated as a topical vehicle. The ME was selected from a phase diagram, selecting a composition based on Tween® 80 (52 %), myristate isopropyl (28 %), and the aqueous phase (water and polyethylene glycol 400, 60:40 w/w) (20 %), which was after replaced by CH and herbal medicines (HM). HM are alternatives to treat candidiasis, and Stryphnodendron adstringens shell extract, characterized by molecular networking, and Melaleuca alternifolia Chell essential oil (46 % of terpinen-4- ol), showed in vitro activity against Candida albicans. Associating CH in ME improved the mechanical properties of the topical formulation, as adhesiveness, which is an advantageous feature for the topical treatment of vul vovaginal candidiasis. |
URI: | http://www.repositorio.ufop.br/jspui/handle/123456789/14107 |
Link para o artigo: | https://www.sciencedirect.com/science/article/abs/pii/S0144861720316556 |
DOI: | https://doi.org/10.1016/j.carbpol.2020.117482 |
ISSN: | 0144-8617 |
Aparece nas coleções: | DEFAR - Artigos publicados em periódicos |
Arquivos associados a este item:
Arquivo | Descrição | Tamanho | Formato | |
---|---|---|---|---|
ARTIGO_AssociatingChitosanMicroemulsion.pdf Restricted Access | 4,32 MB | Adobe PDF | Visualizar/Abrir |
Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.