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Título : | Antibacterial screening of plants from the Brazilian Atlantic Forest led to the identification of active compounds in Miconia latecrenata (DC.) Naudin. |
Autor : | Rodrigues, Laís Azevedo Almeida, Ayla das Chagas Gontijo, Douglas da Costa Salustiano, Iorrana Vieira Almeida, Alisson Andrade Brandão, Geraldo Célio Ribon, Andrea de Oliveira Barros Leite, João Paulo Viana |
Palabras clave : | Bioprospection Hydrolyz able tannins Phenolic compounds |
Fecha de publicación : | 2020 |
Citación : | RODRIGUES, L. A. et al. Antibacterial screening of plants from the Brazilian Atlantic Forest led to the identification of active compounds in Miconia latecrenata (DC.) Naudin. Natural Product Research, 2020. Disponível em: <https://www.tandfonline.com/doi/abs/10.1080/14786419.2020.1802271>. Acesso em: 10 jun. 2021. |
Resumen : | Antibiotic resistance is a serious global threat to public health. This has promoted the research for new drug targets, and the use of other approaches, such as antimicrobial combined therapy. The present study evaluated the antibacterial activity of 88 extracts from Brazilian Atlantic Forest trees. The organic extract from leaves of Miconia latecrenata (EMl) was the most promising for inhibiting the growth of Staphylococcus aureus (0.3 mg/mL) and Pseudomonas aeruginosa (2.5 mg/mL). After the bioguided frac tionation of EMl and metabolite profiling performed by UPLC DAD-MS/MS, the ethyl acetate (AFMl) and aqueous (WFMl) frac tions showed a mixture of phenolic compounds derived from ellagic acid and quercetin. The MIC value of AFMl was two-times lower than EMl for P. aeruginosa, suggesting that these phenolic compounds can perform bioactivity. Furthermore, EMI and AFMl showed synergism with ampicillin and tetracycline for S. aureus and P. aeruginosa, respectively. These findings suggest that extract and fractions of the Miconia latecrenata leaves can be used as therapeutic antibacterial agents. |
URI : | http://www.repositorio.ufop.br/jspui/handle/123456789/14094 |
metadata.dc.identifier.uri2: | https://www.tandfonline.com/doi/abs/10.1080/14786419.2020.1802271 |
metadata.dc.identifier.doi: | https://doi.org/10.1080/14786419.2020.1802271 |
ISSN : | 1478-6427 |
Aparece en las colecciones: | DEFAR - Artigos publicados em periódicos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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ARTIGO_AntibacterialScreeningPlants.pdf Restricted Access | 1,13 MB | Adobe PDF | Visualizar/Abrir |
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