Please use this identifier to cite or link to this item:
http://www.repositorio.ufop.br/jspui/handle/123456789/14094
Title: | Antibacterial screening of plants from the Brazilian Atlantic Forest led to the identification of active compounds in Miconia latecrenata (DC.) Naudin. |
Authors: | Rodrigues, Laís Azevedo Almeida, Ayla das Chagas Gontijo, Douglas da Costa Salustiano, Iorrana Vieira Almeida, Alisson Andrade Brandão, Geraldo Célio Ribon, Andrea de Oliveira Barros Leite, João Paulo Viana |
Keywords: | Bioprospection Hydrolyz able tannins Phenolic compounds |
Issue Date: | 2020 |
Citation: | RODRIGUES, L. A. et al. Antibacterial screening of plants from the Brazilian Atlantic Forest led to the identification of active compounds in Miconia latecrenata (DC.) Naudin. Natural Product Research, 2020. Disponível em: <https://www.tandfonline.com/doi/abs/10.1080/14786419.2020.1802271>. Acesso em: 10 jun. 2021. |
Abstract: | Antibiotic resistance is a serious global threat to public health. This has promoted the research for new drug targets, and the use of other approaches, such as antimicrobial combined therapy. The present study evaluated the antibacterial activity of 88 extracts from Brazilian Atlantic Forest trees. The organic extract from leaves of Miconia latecrenata (EMl) was the most promising for inhibiting the growth of Staphylococcus aureus (0.3 mg/mL) and Pseudomonas aeruginosa (2.5 mg/mL). After the bioguided frac tionation of EMl and metabolite profiling performed by UPLC DAD-MS/MS, the ethyl acetate (AFMl) and aqueous (WFMl) frac tions showed a mixture of phenolic compounds derived from ellagic acid and quercetin. The MIC value of AFMl was two-times lower than EMl for P. aeruginosa, suggesting that these phenolic compounds can perform bioactivity. Furthermore, EMI and AFMl showed synergism with ampicillin and tetracycline for S. aureus and P. aeruginosa, respectively. These findings suggest that extract and fractions of the Miconia latecrenata leaves can be used as therapeutic antibacterial agents. |
URI: | http://www.repositorio.ufop.br/jspui/handle/123456789/14094 |
metadata.dc.identifier.uri2: | https://www.tandfonline.com/doi/abs/10.1080/14786419.2020.1802271 |
metadata.dc.identifier.doi: | https://doi.org/10.1080/14786419.2020.1802271 |
ISSN: | 1478-6427 |
Appears in Collections: | DEFAR - Artigos publicados em periódicos |
Files in This Item:
File | Description | Size | Format | |
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ARTIGO_AntibacterialScreeningPlants.pdf Restricted Access | 1,13 MB | Adobe PDF | View/Open |
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