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Title: Chemical characterization and anti-inflammatory assessment of the hydroethanolic extract of Fridericia chica.
Authors: Takenaka, Isabella Kuniko Tavares Magalhães
Amorim, Juliana Mendes
Barros, Patrícia Aparecida Vieira de
Brandão, Geraldo Célio
Contarini, Sara Moreira Lopes
Melo, Éricka Lorenna de Sales Souza e
Leite, Camila Megale Almeida
Martins, Flaviano dos Santos
Cardoso, Valbert Nascimento
Castilho, Rachel Oliveira
Diniz, Simone Odília Antunes Fernandes
Keywords: Bacterial translocation
Flavonoids rich extract
Intestinal mucositis
Intestinal permeability
Issue Date: 2020
Citation: TAKENAKA, I. K. T. M. et al. Chemical characterization and anti-inflammatory assessment of the hydroethanolic extract of Fridericia chica. Revista Brasileira de Farmacognosia, v. 30, p. 559-567, 2020. Disponível em: <>. Acesso em: 10 jun. 2021.
Abstract: Fridericia chica (Bonpl.) L.G. Lohmann, Bignoniaceae, is an Amazonian species known as “pariri” or “crajiru” that is included in the Brazilian National List of Medicinal Plants of Interest to the Unified Health System (Renisus). This herbal remedy is traditionally used as an infusion to treat diarrhea, anemia, inflammation, symptoms of mucositis, and frequent complications of chemotherapy. This study aimed to characterize the chemical profile of the hydroethanolic extract of F. chica and to assess its intestinal anti-inflammatory activity. The chemical profile of the leaves was determined by ultra-performance liquid chromatog raphy coupled to mass spectrometry, and its potential anti-inflammatory activity in the gut was evaluated in mucositis induced by 5-fluorouracil. Three novel compounds from this the species were identified 6,7,3′,4′-tetrahydroxy-5-methoxyflavilium-O-glu curonide, scutellarein-O-glucuronide, and 5-methyl-scutellarein-O-glucuronide, as well as flavones and anthocyanidins that have been previously described. Mice received the hydroethanolic extract (300 mg/kg) for 9 days, and no signs of toxicity were observed. After 72 h of 5-fluorouracil administration, intestinal permeability, bacterial translocation, myeloperoxidase activity, eosinophil peroxidase activity, and histological analyses were performed. Treatment with the analyzed extract was beneficial, as it normalized intestinal permeability, bacterial translocation, myeloperoxidase activity/eosinophil peroxidase and preserved intestinal epithelium architecture. This study provides new insights into the chemical composition and biological activity of the polar extracts from “pariri”, an important Amazonian crude medicinal drug.
ISSN: 1981-528X
metadata.dc.rights.license: A Revista Brasileira de Farmacognosia permite que o Repositório Institucional da Universidade Federal de Ouro Preto (UFOP) deposite uma cópia eletrônica dos artigos publicados por esse periódico em que ao menos um dos autores faça parte da comunidade cientifica da UFOP. Fonte: Licença concedida mediante prenchimento de formulário em 16 set. 2013.
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