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Title: Cytotoxic, antitumor and toxicological profile of passiflora alata leaf extract.
Authors: Amaral, Ricardo Guimarães
Gomes, Silvana Vieira Floresta
Andrade, Luciana Nalone
Santos, Sara Albuquerque dos
Severino, Patrícia
Albuquerque Júnior, Ricardo Luiz Cavalcanti de
Souto, Eliana B.
Brandão, Geraldo Célio
Santos, Sandra Lauton
David, Jorge Mauricio
Carvalho, Adriana Andrade
Keywords: Natural products
Issue Date: 2020
Citation: AMARAL, R. G. et al. Cytotoxic, antitumor and toxicological profile of passiflora alata leaf extract. Molecules, v. 25, p. 4814, 2020. Disponível em: <>. Acesso em: 10 jun. 2021.
Abstract: Passiflora alata or passion fruit is a native flowering plant from Amazon, geographically spread from Peru to Brazil. The plant has long been used in folks medicine for its pharmacological properties and is included in the Brazilian Pharmacopoeia since 1929. The aim of this study was to evaluate the potential cytotoxic and antitumor activities of Passiflora alata leaf extract (PaLE) in S180-tumor bearing mice. The percentage of cell proliferation inhibition (% CPI) and IC50 in relation to 4 tumor cell lines were determined in PC3, K-562, HepG2 and S180 cell lines using the MTT assay. PaLE showed a CPI > 75% and greater potency (IC50 < 30 µg/mL) against PC3 and S180 cell lines. PaLE showed antitumor activity in treatments intraperitoneally (36.75% and 44.99% at doses of 100 and 150 mg/kg/day, respectively). Toxicological changes were shown in the reduced body mass associated with reduced food consumption, increased spleen mass associated with histopathological increase in the white pulp of the spleen and increased number of total leukocytes with changes in the percentage relationship between lymphocytes and neutrophils. Our outcomes corroborate the conclusion that PaLE has antitumor activity in vitro and in vivo with low toxicity.
ISSN: 1420-3049
metadata.dc.rights.license: This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( Fonte: o PDF do artigo.
Appears in Collections:DEFAR - Artigos publicados em periódicos

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