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Título: | A sustainable UPLC-UV method for quantification of donepezil hydrochloride in biorelevant media applied to dissolution profile comparison. |
Autor(es): | Campos, Débora Priscila de Barcellos, Neila Marcia Silva Marinho, Flávia Dias Marques Barbosa, Guilherme Xavier Lana, Victoria Luiza Vieira Vidigal Souza, Jacqueline de |
Palavras-chave: | Ultra-performance liquid chromatography Green analytical method |
Data do documento: | 2020 |
Referência: | CAMPOS, D. P. de et al. A sustainable UPLC-UV method for quantification of donepezil hydrochloride in biorelevant media applied to dissolution profile comparison. Drug Development and Industrial Pharmacy, 2020. Disponível em: <https://www.tandfonline.com/doi/abs/10.1080/03639045.2020.1810266>. Acesso em: 10 jun. 2021. |
Resumo: | Donepezil hydrochloride is one of the most prescribed anti-Alzheimer’s drugs, despite being available for more than two decades, chromatographic methods for the quantification of the drug in biorelevant media that mimics pH physiological conditions in vivo (pH 1.2, 4.5, and 6.8) are not available in the literature. These media are used in the dissolution test, an important tool, for registration and quality control of medicines. Considering the need for methods with this purpose, this work aimed to develop and validate a sustainable UPLC-UV method for quantification of donepezil hydrochloride in tablets, specifically on assay and dissolution profile, with reduced environmental impacts. The proposed method has a run time of 2 min and requires for each run, only 0.8 mL of solvents, providing excellent green analysis. The method proved to be selective, linear, precise, accurate, robust in the range of 2–14 mg/mL. Three products (reference, similar, and generic) were analyzed and showed very rapid dissolution. The average content varied from 100.2 ± 0.6% to 109.5 ± 2.1%. Using dissolution efficiency (DE), the drug release profiles were com pared in different biorelevant media. |
URI: | http://www.repositorio.ufop.br/jspui/handle/123456789/14091 |
Link para o artigo: | https://www.tandfonline.com/doi/abs/10.1080/03639045.2020.1810266 |
DOI: | https://doi.org/10.1080/03639045.2020.1810266 |
ISSN: | 1520-5762 |
Aparece nas coleções: | DEFAR - Artigos publicados em periódicos |
Arquivos associados a este item:
Arquivo | Descrição | Tamanho | Formato | |
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ARTIGO_SustainableUPLC-UVMethod.pdf Restricted Access | 1,87 MB | Adobe PDF | Visualizar/Abrir |
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