Please use this identifier to cite or link to this item:
Title: Neuroendocrine apendicopathy in morphologically normal appendices of patients with diagnosis of acute appendicitis : diagnostic study.
Authors: Petroianu, Andy
Barroso, Thiago Vinicius Villar
Buzelin, Marcelo Araújo
Theobaldo, Bárbara de Melo
Tafuri, Luciene Simões de Assis
Keywords: Immunohistochemistry
Issue Date: 2020
Citation: PETROIANU, A. et al.Neuroendocrine apendicopathy in morphologically normal appendices of patients with diagnosis of acute appendicitis: diagnostic study. Annals of Medicine and Surgery, v. 60, p. 344-351, 2020. Disponível em: <>. Acesso em: 10 jun. 2021.
Abstract: Background: About 15%–25% of appendices removed to treat acute appendicitis present normal macro- and macroscopic morphology. The objective of this study was to verify an association of proinflammatory, neuro endocrine and immune mediators with morphologically normal appendices removed from patients with clinical laboratorial and imaging characteristics of acute appendicitis. Materials and methods: Appendices removed from 121 adult patients of both genders were distributed into three groups according to their following characteristics: group 1: 53 macro- and microscopically normal appendices from patients with clinical, laboratorial and imaging diagnosis of acute appendicitis; group 2: 24 inflamed appendices from patients with clinical, laboratorial, imaging and histopathological diagnosis of acute appendi citis; group 3: 44 normal appendices from patients submitted to right colectomy to treat localized ascending colon adenocarcinoma. All appendices were immunohistochemically studied for gastrin inhibitor peptide, mast cell tryptase, vascular endothelial growth factor; intestinal vasoactive peptide, tumor necrosis factor alpha, interleukin 1, prostaglandin E2, gene-protein product 9.5, CD8 T lymphocytes, synaptophysine, enolase, and S100 protein. Results: The group 1 revealed increased levels of synaptophysine, enolase, mast cell tryptase and PGP-9.5 comparing with the other two groups. The group 2 presented increased levels of interleukin 1, CD8 T lympho cytes and prostaglandin E2 comparing with the other two groups. The group 3 confirmed the normal levels of all these neuroendocrine, immune and proinflammatory mediators. Conclusions: Morphologically normal appendices removed from patients with clinical and complementary exams indicating acute appendicitis have appendicular neuroimmunoendocrine disorder associated with the mediators synaptophysin, enolase, mast cell-related tryptase and gene-protein product 9.5.
ISSN: 2049-0801
metadata.dc.rights.license: This is an open access article under the CC BY license ( Fonte: o PDF do artigo.
Appears in Collections:DECGP - Artigos publicados em periódicos

Files in This Item:
File Description SizeFormat 
ARTIGO_NeuroendocrineApendicopathyMorphologically.pdf3,31 MBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.