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dc.contributor.authorBernardes, Ana Catharina Fernandes Pereira Ferreira-
dc.contributor.authorMatosinhos, Rafaela Cunha-
dc.contributor.authorAraújo, Marcela Carolina de Paula Michel-
dc.contributor.authorBarros, Camila Helena-
dc.contributor.authorSoares, Rodrigo Dian de Oliveira Aguiar-
dc.contributor.authorCosta, Daniela Caldeira-
dc.contributor.authorSachs, Daniela-
dc.contributor.authorGuimarães, Dênia Antunes Saúde-
dc.date.accessioned2021-11-22T11:59:02Z-
dc.date.available2021-11-22T11:59:02Z-
dc.date.issued2021pt_BR
dc.identifier.citationBERNARDES, A. C. F. P. F. et al. Sesquiterpene lactones from Lychnophora species: antinociceptive, anti-inflammatory, and antioxidant pathways to treat acute gout. Journal of Ethnopharmacology, v. 269, p. 113738, 2021. Disponível em: <https://www.sciencedirect.com/science/article/abs/pii/S0378874120336266>. Acesso em: 10 jun. 2021.pt_BR
dc.identifier.issn0378-8741-
dc.identifier.urihttp://www.repositorio.ufop.br/jspui/handle/123456789/13986-
dc.description.abstractEthnopharmacological relevance: Lychnophora trichocarpha and Lychnophora passerina are species used in folk medicine to treat inflammation, pain, and rheumatism. Previous studies have demonstrated the antiinflammatory effect of ethanol extracts of these species and identified that sesquiterpene lactones contribute to this activity. Aim of the study: Gout is an acute inflammatory arthritis caused by the deposition of monosodium urate (MSU) crystals in joints. Inflammation in joints induces oxidative stress in defense cells, releasing pro-inflammatory mediators. This study has three objectives: (1) to demonstrate the effects of sesquiterpene lactones lychnopholide and eremantholide C isolated from L. trichocarpha and goyazensolide isolated from L. passerina on arthritis induced by MSU crystals in C57BL6 mice; (2) to determine whether or not these compounds can inhibit the migration of neutrophils and the release of TNF-α and IL-1β cytokines in the inflammation region; and (3) to evaluate the effects of sesquiterpene lactones on the activities of the antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT) in the cartilage of C57BL/6 mice with gouty arthritis. Materials and methods: The anti-inflammatory, antinociceptive, and antioxidant activities of sesquiterpene lactones in C57BL/6 mice with MSU crystal-induced arthritis were evaluated. In our experimental model, the mice were injected with MSU crystals in the tibiofemoral joint to induce arthritis and then treated with indomethacin, vitamin C, and sesquiterpene lactones. Nociception was evaluated before and after inflammation induction and treatments, neutrophil migration, IL-1β and TNF-α concentrations, and SOD and CAT activities. Results: Sesquiterpene lactones exerted an anti-inflammatory effect by inhibiting neutrophil migration and TNF-α production. These compounds also demonstrated antinociceptive and antioxidant activities. Conclusion: Lychnopholide, eremantholide C, and goyazensolide improved the inflammation induced by MSU crystals by inhibiting the migration of neutrophils to the inflamed area and by blocking the release of the proinflammatory cytokine TNF-α. In addition, sesquiterpene lactones reduced oxidative stress by activating SOD and CAT. These results suggest that sesquiterpene lactones have anti-gout activity through the inflammation, pain, and oxidative stress pathways.pt_BR
dc.language.isoen_USpt_BR
dc.rightsrestritopt_BR
dc.subjectArthritispt_BR
dc.subjectNeutrophilpt_BR
dc.subjectPainpt_BR
dc.subjectCytokinept_BR
dc.titleSesquiterpene lactones from Lychnophora species : antinociceptive, anti-inflammatory, and antioxidant pathways to treat acute gout.pt_BR
dc.typeArtigo publicado em periodicopt_BR
dc.identifier.uri2https://www.sciencedirect.com/science/article/abs/pii/S0378874120336266pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.jep.2020.113738pt_BR
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