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Title: Susceptibility to re-infection in C57BL/6 mice with recombinant strains of Toxoplasma gondii.
Authors: Brandão, Geane Peroni
Melo, Maria Norma
Caetano, Bráulia Costa
Carneiro, Cláudia Martins
Silva, Letícia de Azevedo
Vitor, Ricardo Wagner de Almeida
Keywords: Experimental toxoplasmosis
Recombinant strains
Issue Date: 2011
Citation: BRANDÃO, G. P. et al. Susceptibility to re-infection in C57BL/6 mice with recombinant strains of Toxoplasma gondii. Experimental Parasitology, v. 128, n. 4, p. 433–437, ago. 2011. Disponível em: <>. Acesso em: 11 set. 2012.
Abstract: This work reports results of re-infection of BALB/c and C57BL/6 mice with different recombinant strains of Toxoplasma gondii. Mice were prime-infected with the non-virulent D8 strain and challenged with virulent strains. PCR–RFLP of cS10-A6 genetic marker of T. gondii demonstrated that BALB/c mice were reinfected with the EGS strain, while C57BL/6 mice were re-infected with the EGS and CH3 strains. Levels of IFN-c and IL-10 after D8 prime-infection were lower in C57BL/6 than in BALB/c mice. Brain inflammation after D8 prime-infection was more intense in C57BL/6 than in BALB/c mice. It was shown that reinfection depends on mice lineage and genotype of the strain used in the challenge.
ISSN: 00144894
metadata.dc.rights.license: O periódico Experimental Parasitology concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3280861265494.
Appears in Collections:DEACL - Artigos publicados em periódicos

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